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IGC-AD1-Active

Phase 2

Alzheimer Disease | Small molecule | Neurology |IGC Pharma, Inc.|Last Updated: May 20, 2026

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDDMC
Total Trials1
Total Enrollment164
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT05543681Clinical Trial on Agitation in Alzheimer's DementiaPHASE2 RECRUITING 164Oct 11, 2022Aug 1, 2026May 20, 202631 United States, Canada +2
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Study Endpoints
Primary Endpoints
Agitation
Baseline to week six

Change in mean Cohen Mansfield Agitation Inventory (CMAI) score

Secondary Endpoints
Acute Agitation
Baseline to week two
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Study Design & Arms
AllocationRANDOMIZED
MaskingTRIPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Active Comparator: IGC-AD1ActiveACTIVE_COMPARATORIGC-AD1-Active, oral solution with two APIs (THC and melatonin).
Placebo Comparator: IGC-AD1 PlaceboPLACEBO_COMPARATORIGC-AD1-Placebo, oral solution similar to Active in color, taste, and texture, with excipients but without APIs.
Interventions
NameTypeDescription
IGC-AD1-ActiveDRUGA non-sterile solution for oral administration.
IGC-AD1-PlaceboDRUGA non-sterile solution for oral administration similar in color and texture to the Active.
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Eligibility Criteria
Age Range60 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites31

To be eligible to participate in this study, the participant must meet all the following criteria: Inclusion Criteria 1. Participant and/or Caregiver must provide a signed and dated ICF prior to any study procedures. 2. Must have a Caregiver who is able and willing to comply with all required stud...

Countries:United StatesCanadaColombiaPuerto Rico
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Recent Changes (Last 90 Days)
MEDIUMMay 26, 2026NCT05543681primaryCompletionDate: changed
LOWMay 24, 2026NCT05543681studyFirstPostDate: changed