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NSC001

Phase 1

Alzheimer Disease | Small molecule | Neurology |cbdMD, Inc.|Last Updated: Apr 17, 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment90

FDA Designations

No designations recorded

Clinical trial landscape

NSC001 · 1 trial · 1 indication

Phase 1 1
NCT06995573A Study to Assess Safety and Tolerability and to Explore Efficacy of NSC001 in Mild to Moderate Alzheimer's DiseaseAlzheimer Disease
RECRUITING90 Analytics
PHASE1RECRUITING
A Study to Assess Safety and Tolerability and to Explore Efficacy of NSC001 in Mild to Moderate Alzheimer's Disease
Alzheimer DiseaseUnlock trial analytics

Study Endpoints

Primary Endpoints

Safety and tolerability of NSC001
Week 0 and week16

Number of Adverse Events (AEs) between V1 (Baseline) -V5 (End of Treatment)

Safety during the treatment period
Week 0 and week16

Number of Serious Adverse Events (SAEs) between V1 (Baseline) -V5 (End of Treatment)

Secondary Endpoints

Maximum concentration in plasma
At week 0, 1, 2, 3, 4, 16 at pre-dose, 0.5, 1, 1.5, 2, 2.5, 3, 4 and 6 hours)
Time at maximum concentration in plasma
At week 0, 1, 2, 3, 4, 16 at pre-dose, 0.5, 1, 1.5, 2, 2.5, 3, 4 and 6 hours)
Area under the curve
At week 0, 1, 2, 3, 4, 16 at pre-dose, 0.5, 1, 1.5, 2, 2.5, 3, 4 and 6 hours)
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Study Design & Arms

AllocationRANDOMIZED
MaskingTRIPLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Arm 1EXPERIMENTAL40 mg QD of NSC001
Arm 2EXPERIMENTAL40 mg QD of NSC001 + 20 mg of Trospium
Arm 3PLACEBO_COMPARATORPlacebo: with or without 20 mg of Trospium

Interventions

NameTypeDescription
NSC001DRUGrigid, orthosteric acetylcholine analog, highly specific for M1 muscarinic receptor
PlaceboOTHERmatching placebo to NSC001
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Eligibility Criteria

Age Range50 Years to 85 Years
SexALL
Healthy VolunteersNo
Study Sites10

Inclusion Criteria: * Participants and competent trial partner/caregiver are willing and able to give signed informed consent for participation in the trial including compliance with the requirements and restrictions according to local regulations for the trial Informed Consent Form (ICF). Signed i...

Countries:AustriaGermany
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Frequently asked questions about NSC001

What is NSC001 used for in Alzheimer Disease?

NSC001 is an investigational small molecule being developed for the treatment of mild to moderate Alzheimer's Disease. It is currently in Phase 1 clinical development and has not been approved by regulatory authorities. The drug is being studied for its safety, tolerability, and potential efficacy in patients with this condition.

Who makes NSC001?

NSC001 is being developed by cbdMD, Inc., a company traded on the NYSE American under the ticker symbol YCBD. The company is conducting clinical research on this investigational small molecule for Alzheimer's Disease, with the drug currently in Phase 1 development.

What phase is NSC001 in?

NSC001 is currently in Phase 1 clinical development. It is an investigational drug and has not been approved by the FDA or any other regulatory agency. The ongoing Phase 1 trial is designed to assess the safety, tolerability, and preliminary efficacy of NSC001 in patients with mild to moderate Alzheimer's Disease.

What clinical trials is NSC001 in?

NSC001 is being evaluated in a single Phase 1 clinical trial registered as NCT06995573. This randomized, double-blind, placebo-controlled study is recruiting 90 participants aged 50 years and older with mild to moderate Alzheimer's Disease. The trial is being conducted at sites in Austria and Germany and is currently in the recruiting phase.

How does NSC001 work?

NSC001 is a small molecule being investigated for the treatment of Alzheimer's Disease. The specific molecular target of NSC001 has not been disclosed in available information. The ongoing Phase 1 trial is designed to explore the drug's safety, tolerability, and potential efficacy in patients with mild to moderate Alzheimer's Disease.