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Plamotamab

Phase 1

Rheumatoid Arthritis | Monoclonal antibody | Immunology |Xencor, Inc.|Last Updated: Apr 14, 2026

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment68
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT07230353A Phase 1b Open-label Study to Evaluate Safety of Plamotamab in Participants With Rheumatoid ArthritisPHASE1 RECRUITING 68Oct 21, 2025Jun 1, 2028Apr 14, 20263 Georgia, Moldova +1
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Study Endpoints
Primary Endpoints
Primary
Through Week 52

Percentage of participants with treatment emergent adverse events (TEAEs) and serious adverse events (SAEs)

Secondary Endpoints
Secondary
Through Week 52
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Study Design & Arms
AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Dose EscalationEXPERIMENTALPlamotamab administered SC
Interventions
NameTypeDescription
PlamotamabBIOLOGICALBiological
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites3

Inclusion Criteria: Adult participants with moderately to severely active RA. * Documented diagnosis of RA and meeting the 2010 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for RA at least 3 months prior to screening * Inadequate respon...

Countries:GeorgiaMoldovaNew Zealand
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Recent Changes (Last 90 Days)
MEDIUMMay 26, 2026NCT07230353Enrollment: 47 → 68
LOWMay 24, 2026NCT07230353studyFirstPostDate: changed