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VP4896

Phase 3

Alzheimer's Disease | Small molecule | Neurology |Voyager Therapeutics, Inc.|Last Updated: Sep 20, 2007

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindUNCONTROLLED
Total Trials1
Total Enrollment555

FDA Designations

No designations recorded

Clinical trial landscape

VP4896 · 1 trial · 1 indication

Phase 3 1
NCT00231946ALADDIN Study - Phase III: Antigonadotropin-Leuprolide in Alzheimer's Disease Drug INvestigation (VP-AD-301)Alzheimer's Disease
COMPLETED555 Analytics
PHASE3COMPLETED
ALADDIN Study - Phase III: Antigonadotropin-Leuprolide in Alzheimer's Disease Drug INvestigation (VP-AD-301)
Alzheimer's DiseaseUnlock trial analytics

Study Endpoints

Primary Endpoints

Cognitive assessment and Caregiver's impression of change at baseline and at weeks 8, 24, 34, and 50.

Secondary Endpoints

Ability to perform Activities of Daily Living (ADL) at baseline and weeks 8, 24, 34, and 50. Impression of disease severity assessment at week 50.
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT

Interventions

NameTypeDescription
VP4896DRUG -
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Eligibility Criteria

Age Range60 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites59

Inclusion Criteria: * 60 years of age or older * Diagnosis of probable mild-to-moderate Alzheimer's Disease * On a stable dose of an acetylcholinesterase inhibitor (including, but not limited to: donepezil, galantamine, rivastigmine, and tacrine) for at least 120 days prior to baseline and will lik...

Countries:United StatesCanada
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Frequently asked questions about VP4896

What is VP4896 used for?

VP4896 is an investigational small molecule being studied for the treatment of Alzheimer's Disease. It is currently in Phase 3 clinical development and has not been approved by regulatory authorities. The drug is being evaluated in patients aged 60 years and older.

Who makes VP4896?

VP4896 is being developed by Voyager Therapeutics, Inc., a biopharmaceutical company traded on the NASDAQ under the ticker symbol VYGR. The company is conducting clinical trials to evaluate the drug's safety and efficacy in Alzheimer's Disease.

What phase is VP4896 in?

VP4896 is in Phase 3 clinical development for Alzheimer's Disease. It is an investigational drug, meaning it has not yet received regulatory approval and is still undergoing clinical trials to assess its safety and effectiveness in the target patient population.

What clinical trials is VP4896 in?

VP4896 has one completed Phase 3 clinical trial registered under NCT00231946, titled the ALADDIN Study. This randomized, double-blind trial enrolled 555 participants with Alzheimer's Disease across the United States and Canada, with a minimum age of 60 years.

Is VP4896 the same as VP-AD-301?

VP4896 is associated with the clinical trial VP-AD-301, which is the study identifier for the ALADDIN Phase 3 trial. The drug is being investigated under this trial protocol for the treatment of Alzheimer's Disease, though the drug itself is referred to as VP4896.