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SR57667B

Phase 2

Alzheimer Disease | Small molecule | Neurology |Sanofi|Last Updated: Dec 23, 2008

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindUNCONTROLLED
Total Trials2
Total Enrollment890

FDA Designations

No designations recorded

Clinical trial landscape

SR57667B · 4 trials · 2 indications

Phase 2 4
NCT00285025Study of the Effect of SR57667B in Patients With Alzheimer's DiseaseAlzheimer Disease
COMPLETED500 Analytics
NCT00285077Long-Term Safety Extension With SR57667B in Patients With Alzheimer's DiseaseAlzheimer Disease
COMPLETED390 Analytics
NCT00220272Study of the Effect of SR57667B on 18F-Dopa PET Imaging in Patients With Parkinson's DiseaseParkinson Disease
COMPLETED183 Analytics
NCT00228150Study of the Effect of SR57667B on the Progression of Symptoms in Patients With Parkinson's DiseaseParkinson Disease
COMPLETED564 Analytics
PHASE2COMPLETED
Study of the Effect of SR57667B in Patients With Alzheimer's Disease
Alzheimer DiseaseUnlock trial analytics
PHASE2COMPLETED
Long-Term Safety Extension With SR57667B in Patients With Alzheimer's Disease
Alzheimer DiseaseUnlock trial analytics
PHASE2COMPLETED
Study of the Effect of SR57667B on 18F-Dopa PET Imaging in Patients With Parkinson's Disease
Parkinson DiseaseUnlock trial analytics
PHASE2COMPLETED
Study of the Effect of SR57667B on the Progression of Symptoms in Patients With Parkinson's Disease
Parkinson DiseaseUnlock trial analytics

Study Endpoints

Primary Endpoints

ADAS-cog, CDR measured at baseline and at 2, 6, 9 and 12 months.
Adverse events recorded quarterly.
Change in average (left and right) putamen 18F-Dopa influx constant (Ki) from baseline to two year 18F-Dopa PET
Time to disability warranting introduction of Ldopaor a dopamine agonist.

Secondary Endpoints

MMSE, CGIC, ADCS-ADL, NPI measured at baseline and at 2, 6, 9 and 12 months.
ADAS-cog, CDR, MMSE, CGIC, ADCS-ADL, NPI measured at baseline and at 2,6,9 and 12 months.
Unified Parkinson's Disease Rating Scale (UPDRS)
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT

Interventions

NameTypeDescription
SR57667BDRUG -
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Eligibility Criteria

Age Range50 Years to N/A
SexALL
Healthy VolunteersNo

Inclusion Criteria: * Male / female outpatients. * Age \> 50 years at screening. * Dementia of Alzheimer's Type (DSM-IV 290.0) according to DSM-IV criteria, Probable AD according to NINCDS-ADRDA criteria, Mini-Mental State Examination score \> 12 and \< 26. * Untreated or treated for a minimum of 6...

Countries:CanadaDenmarkFinlandFranceGermanySouth AfricaSwedenNetherlandsSpainSwitzerlandUnited KingdomAustriaMoroccoPortugalTunisia
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Frequently asked questions about SR57667B

What is SR57667B used for?

SR57667B is an investigational small molecule being studied for the treatment of Alzheimer's disease and Parkinson's disease. It is in Phase 2 clinical development, with completed trials in both neurological conditions. The drug is not approved and remains under investigation.

Who makes SR57667B?

SR57667B is being developed by Sanofi, a multinational pharmaceutical company listed on the stock exchange under the ticker SNY. Sanofi is conducting Phase 2 clinical trials to evaluate the drug's effects in patients with Alzheimer's disease and Parkinson's disease.

What phase is SR57667B in?

SR57667B is in Phase 2 clinical development. All four clinical trials for this drug have been completed, including studies in Alzheimer's disease and Parkinson's disease. The drug is investigational and has not received FDA approval.

What clinical trials is SR57667B in?

SR57667B has completed four Phase 2 trials. These include NCT00220272 and NCT00228150 in Parkinson's disease, and NCT00285025 and NCT00285077 in Alzheimer's disease. The trials enrolled a total of 890 participants across multiple countries.

Is SR57667B the same as any other drug?

No alternative names for SR57667B have been reported. The drug is identified solely by its code name SR57667B in clinical trial registries and development programs by Sanofi.