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anti-Abeta

Phase 1

Alzheimer's Disease | Small molecule | Neurology |Roche Holding AG|Last Updated: Oct 27, 2010

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindUNCONTROLLED
Total Trials1
Total Enrollment56

FDA Designations

No designations recorded

Clinical trial landscape

anti-Abeta · 1 trial · 1 indication

Phase 1 1
NCT00736775A Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Anti-Abeta (MABT5102A) in Patients With Alzheimer's DiseaseAlzheimer's Disease
COMPLETED56 Analytics
PHASE1COMPLETED
A Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Anti-Abeta (MABT5102A) in Patients With Alzheimer's Disease
Alzheimer's DiseaseUnlock trial analytics

Study Endpoints

Primary Endpoints

Safety and tolerability of single and multiple doses of MABT5102A
Through study completion or early study discontinuation

Secondary Endpoints

Pharmacokinetics of MABT5102A after single and multiple doses
Through study completion or early study discontinuation
Immunogenicity of MABT5102A after single and multiple doses
Through study completion or early study discontinuation
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT

Interventions

NameTypeDescription
anti-AbetaDRUGIntravenous single and multiple doses
placeboDRUGIntravenous single and multiple doses
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Eligibility Criteria

Age Range50 Years to 86 Years
SexALL
Healthy VolunteersNo

Inclusion Criteria: * Diagnosis of probable AD according to the NINCDS-ADRDA Criteria * Approved AD treatments (AchE inhibitors+/-memantine) must be stable for ≥ 3 months prior to screening * Other prescription medications must be stable for ≥ 1 month prior to screening Exclusion Criteria: * Fema...

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Frequently asked questions about anti-Abeta

What is anti-Abeta used for in Alzheimer's Disease?

Anti-Abeta is an investigational small molecule being studied for the treatment of Alzheimer's Disease. It is currently in Phase 1 clinical development, meaning it has not yet been approved for use. The drug is being evaluated for its safety, pharmacokinetics, pharmacodynamics, and immunogenicity in patients with the condition.

Who makes anti-Abeta?

Anti-Abeta is being developed by Roche Holding AG, a multinational healthcare company. Roche's stock is traded under the ticker symbol RHHBY. The company is conducting clinical research to evaluate the drug's potential in treating Alzheimer's Disease.

What phase is anti-Abeta in?

Anti-Abeta is currently in Phase 1 clinical development. It is an investigational drug, meaning it has not been approved by regulatory authorities. The drug is being studied for its safety and other characteristics in patients with Alzheimer's Disease, but it is not yet available for clinical use.

What clinical trials is anti-Abeta in?

Anti-Abeta has been studied in one clinical trial with the identifier NCT00736775. This Phase 1 study, titled "A Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Anti-Abeta (MABT5102A) in Patients With Alzheimer's Disease," has been completed. The trial enrolled 56 participants and was randomized and double-blind.

Is anti-Abeta the same as MABT5102A?

Yes, anti-Abeta is also known as MABT5102A. In the clinical trial NCT00736775, the drug is referred to as anti-Abeta (MABT5102A). This alternative name may be used in scientific literature and regulatory documents, so readers searching for either name will find information about the same investigational drug.