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LY4006895

Phase 1

Alzheimer Disease | Small molecule | Neurology |Eli Lilly and Company|Last Updated: Jun 4, 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment128

FDA Designations

No designations recorded

Clinical trial landscape

LY4006895 · 1 trial · 2 indications

Phase 1 1
NCT06657768A Study of LY4006895 in Healthy Participants With Early Symptomatic Alzheimer's Disease (AD)Alzheimer Disease
RECRUITING128 Analytics
PHASE1RECRUITING
A Study of LY4006895 in Healthy Participants With Early Symptomatic Alzheimer's Disease (AD)
Alzheimer DiseaseUnlock trial analytics

Study Endpoints

Primary Endpoints

Number of Participants with One or More Treatment Emergent Adverse Events (TEAEs), Serious Adverse Event(s) (SAEs), and Discontinuations due to Adverse Event(s) (AEs) Considered by the Investigator to be Related to Study Drug Administration
Baseline to Study Completion (Up to 61 Weeks)

A summary of TEAEs, SAEs, and AEs regardless of causality, will be reported in the Reported Adverse Events module

Secondary Endpoints

PK: Maximum Concentration (Cmax) of LY4006895
Baseline to Study Completion (Up to 61 Weeks)
PK: Area Under the Concentration Versus Time Curve (AUC) of LY4006895
Baseline to Study Completion (Up to 61 Weeks)
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
LY4006895 of Part A (SAD)EXPERIMENTALSingle-ascending doses of LY4006895 administered intravenously (IV)
Placebo Part APLACEBO_COMPARATORPlacebo administered IV
LY4006895 of Part B (MAD)EXPERIMENTALMultiple-ascending doses of LY4006895 will be administered IV
Placebo Part BPLACEBO_COMPARATORPlacebo administered IV

Interventions

NameTypeDescription
LY4006895DRUGAdministered IV
PlaceboDRUGAdministered IV
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Eligibility Criteria

Age Range45 Years to 85 Years
SexALL
Healthy VolunteersYes
Study Sites13

Inclusion Criteria for Part A and Part B: \- Have a body mass index (BMI) within the range 18 to 40 kilogram per square meter (kg/m²) For Part A: * Are overtly healthy as determined by medical evaluation. Rescreening is not allowed in this study For Part B: * Have early symptomatic AD, as defin...

Countries:United StatesJapan
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Frequently asked questions about LY4006895

What is LY4006895 used for?

LY4006895 is an investigational small molecule being developed for Alzheimer's disease. It is currently in Phase 1 clinical development, studied in healthy participants and those with early symptomatic Alzheimer's disease. The drug is being developed by Eli Lilly and Company.

What does LY4006895 target?

LY4006895 is a small molecule, but its specific molecular target has not been disclosed. It is being studied for its potential effect in Alzheimer's disease, a neurological condition. The mechanism of action is not publicly detailed at this time.

Who makes LY4006895?

LY4006895 is being developed by Eli Lilly and Company, a pharmaceutical company traded on the New York Stock Exchange under the ticker LLY. The company is conducting a Phase 1 clinical trial of the drug in the United States and Japan.

What phase is LY4006895 in?

LY4006895 is in Phase 1 clinical development. It is an investigational drug, not yet approved by regulatory authorities. A Phase 1 study is currently recruiting participants to evaluate the drug in healthy individuals and those with early symptomatic Alzheimer's disease.

What clinical trials is LY4006895 in?

LY4006895 is being studied in one Phase 1 clinical trial, identified as NCT06657768. This randomized, double-blind, placebo-controlled study is recruiting 128 participants in the United States and Japan. The trial includes healthy volunteers and individuals with early symptomatic Alzheimer's disease.

Is LY4006895 the same as any other drug?

LY4006895 is a unique investigational drug candidate developed by Eli Lilly and Company. No alternative names for this compound have been disclosed. It is being studied specifically for Alzheimer's disease and is not known to be identical to any other marketed medication.