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SRA-333

Phase 2

Alzheimer's Disease | Small molecule | Neurology |Pfizer, Inc.|Last Updated: Sep 4, 2009

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindUNCONTROLLED
Total Trials1
Total Enrollment16
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00151333Study Evaluating SRA-333 in Mild to Moderate Alzheimer's Disease (AD)PHASE2 COMPLETED 16Feb 1, 2005Apr 1, 2005Sep 4, 20093 United States
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Study Endpoints
Primary Endpoints
To determine the safety and tolerability of multiple ascending fixed oral dose in subject with mild to moderate Alzheimer's Disease
Secondary Endpoints
To assess the pharmacokinetics and pharmacodynamics of multiple ascending fixed dose.
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Interventions
NameTypeDescription
SRA-333DRUG -
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Eligibility Criteria
Age Range50 Years — 85 Years
SexALL
Healthy VolunteersNo
Study Sites3

Inclusion Criteria: * Diagnosis of probable AD according to the NINCDS-ADRDA criteria. * Men and postmenopausal or surgically sterile women aged from 50 to 85 inclusive. * Able to give informed consent. Patient's caregiver must consent to participate in the study. Exclusion Criteria: * Significan...

Countries:United States
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