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NSA-789

Phase 1

Alzheimer Disease | Small molecule | Neurology |Pfizer, Inc.|Last Updated: Aug 20, 2021

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment24

FDA Designations

No designations recorded

Clinical trial landscape

NSA-789 · 3 trials · 3 indications

Phase 1 3
NCT00795730Multiple Dose Study Evaluating the Safety and Tolerability of NSA-789Alzheimer Disease
COMPLETED24 Analytics
NCT00619736Study Evaluating the Safety, Tolerability and Pharmacokinetics of NSA-789 in Healthy Japanese Male SubjectsHealthy
COMPLETED56 Analytics
NCT00633048Study Evaluating the Safety and Tolerability of NSA-789Healthy
COMPLETED64 Analytics
PHASE1COMPLETED
Multiple Dose Study Evaluating the Safety and Tolerability of NSA-789
Alzheimer DiseaseUnlock trial analytics
PHASE1COMPLETED
Study Evaluating the Safety, Tolerability and Pharmacokinetics of NSA-789 in Healthy Japanese Male Subjects
HealthyUnlock trial analytics
PHASE1COMPLETED
Study Evaluating the Safety and Tolerability of NSA-789
HealthyUnlock trial analytics

Study Endpoints

Primary Endpoints

Adverse event monitoring as specific tests that will be done to monitor safety (ECGs, certain laboratory tests, vital signs) and tolerability
6 months
Safety and Tolerability
3 months
Safety and tolerability from reported adverse events, scheduled physical examinations, vital signs, cardiac rhythm monitoring, 12-lead ECGs, and clinical laboratory test results
3 months

Secondary Endpoints

Pharmacokinetic and pharmcodynamic parameters
6 months
Pharmacokinetics
3 months
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Study Design & Arms

AllocationRANDOMIZED
MaskingTRIPLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
placeboPLACEBO_COMPARATOR -
NSA-789EXPERIMENTAL -

Interventions

NameTypeDescription
NSA-789DRUG -
placeboOTHER -
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Eligibility Criteria

Age Range18 Years to 99 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria * Men or women aged 18 - 50 years (healthy subjects) or greater than 55 years old (subjects with Alzheimer's Disease) * Women must be surgically sterile or postmenopausal * Subjects with Alzheimer's Disease must be generally healthy, but may have a stable, chronic illness if well...

Countries:United States
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Frequently asked questions about NSA-789

What is NSA-789 used for?

NSA-789 is an investigational small molecule being studied for Alzheimer disease and for use in healthy volunteers. It is in Phase 1 clinical development and is not approved by the FDA. The drug is being evaluated for safety, tolerability, and pharmacokinetics in early-stage trials.

Who makes NSA-789?

NSA-789 is being developed by Pfizer, Inc., a biopharmaceutical company traded on the New York Stock Exchange under the ticker symbol PFE. The drug is currently in Phase 1 clinical development for Alzheimer disease and healthy volunteer studies.

What phase is NSA-789 in?

NSA-789 is in Phase 1 clinical development. It is an investigational drug and has not been approved by the FDA. All completed trials for NSA-789 are Phase 1 studies evaluating safety, tolerability, and pharmacokinetics in healthy subjects and in Alzheimer disease patients.

What clinical trials is NSA-789 in?

NSA-789 has completed three Phase 1 clinical trials. NCT00619736 evaluated safety and pharmacokinetics in healthy Japanese male subjects. NCT00633048 studied safety and tolerability in healthy adults in the United States. NCT00795730 assessed multiple-dose safety and tolerability in Alzheimer disease patients and healthy subjects.

Is NSA-789 the same as other drugs?

NSA-789 is the drug name used in clinical trials registered with ClinicalTrials.gov. No alternative names for NSA-789 have been disclosed in the trial records, and the drug is identified solely by this designation in the studies conducted by Pfizer.