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Lipitor

Phase 1

Hypercholesterolemia | Small molecule | Metabolic |Pfizer, Inc.|Last Updated: Feb 18, 2021

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedCONTROLLED
Total Trials1
Total Enrollment76
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00777517Bioequivalence Study On Pediatric Appropriate FormulationPHASE1 COMPLETED 76Nov 1, 2008Feb 1, 2009Feb 18, 20211 Singapore
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Study Endpoints
Primary Endpoints
Primary study endpoints will be AUClast, AUCinf (if data permit) and Cmax from plasma atorvastatin concentration data.
5 months
Secondary Endpoints
Secondary endpoints will include Tmax and t1/2 (if data permit) of atorvastatin ; AUClast, AUCinf, Cmax, Tmax, and t1/2 (if data permit) of o-hydroxyatorvastatin and p-hydroxyatorvastatin.
5 months
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeOTHER
Treatment Arms
ArmTypeDescription
ReferenceOTHERCommercial 10 mg Lipitor formulation tablet
TestOTHERAtorvastatin pediatric formulation
Interventions
NameTypeDescription
LipitorDRUGA single dose of 10 mg Lipitor tablet
Atorvastatin pediatric formulationDRUGA single dose of 10 mg atorvastatin pediatric formulation
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Eligibility Criteria
Age Range18 Years — 55 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Healthy male and/or female subjects * Mass Index (BMI) of approximately 18 to 30 kg/m2 Exclusion Criteria: * Any condition possibly affecting drug absorption * A positive urine drug screening

Countries:Singapore
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