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FX201

Phase 1

Osteoarthritis, Knee | Monoclonal antibody | Musculoskeletal |Pacira BioSciences, Inc.|Last Updated: Mar 17, 2025

Success Probability

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Market & Valuation

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Trial Design

CONTROLLEDDMC
Total Trials1
Total Enrollment72

FDA Designations

No designations recorded

Clinical trial landscape

FX201 · 1 trial · 1 indication

Phase 1 1
NCT04119687Study to Evaluate the Safety and Tolerability of FX201 in Patients with Osteoarthritis of the KneeOsteoarthritis, Knee
ACTIVE NOT_RECRUITING72 Analytics
PHASE1ACTIVE NOT_RECRUITING
Study to Evaluate the Safety and Tolerability of FX201 in Patients with Osteoarthritis of the Knee
Osteoarthritis, KneeUnlock trial analytics

Study Endpoints

Primary Endpoints

Primary Outcome Measure: Incidence of treatment emergent adverse events after a single intra-articular (IA) injection of FX201 (safety and tolerability)
Baseline to Week 104

Incidence of treatment emergent adverse events after a single intra-articular (IA) injection of FX201

Secondary Endpoints

Secondary Outcome Measure: Characterization of the systemic biodistribution of FX201 as seen through the percentage of patients positive for FX201 at Baseline, Day 1, Day 2, Week 1, Week 2, Week 3, and Week 4
Baseline, Day 1, Day 2, Week 1, Week 2, Week 3, Week 4
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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingNONE
ModelSEQUENTIAL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Low Dose FX201EXPERIMENTALSingle low dose FX201 injection
Mid Dose FX201EXPERIMENTALSingle mid dose FX201 injection
High Dose FX201EXPERIMENTALSingle high dose FX201 injection

Interventions

NameTypeDescription
FX201BIOLOGICALFX201, humantakinogene hadenovec, is a novel interleukin-1 receptor antagonist (IL-1Ra) gene therapy for IA administration that is being developed for the treatment of patients with OAK.
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Eligibility Criteria

Age Range30 Years to 80 Years
SexALL
Healthy VolunteersNo
Study Sites6

Inclusion Criteria: * Written consent to participate in the study * Male or female 30 to 80 years of age, inclusive, on the day of enrollment (Day 1) * Body mass index (BMI) ≤ 40 kilograms per meters squared (kg/m2) * Clinical diagnosis of OA of the knee on the American College of Rheumatology crit...

Countries:United States
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Frequently asked questions about FX201

What is FX201 used for?

FX201 is an investigational monoclonal antibody being developed for the treatment of osteoarthritis of the knee. It is currently in Phase 1 clinical development and has not been approved by the FDA. The drug is being studied in patients with this condition to evaluate its safety and tolerability.

Who makes FX201?

FX201 is being developed by Pacira BioSciences, Inc., a biopharmaceutical company traded on the NASDAQ under the ticker symbol PCRX. The company is conducting clinical trials to evaluate the safety and tolerability of FX201 in patients with osteoarthritis of the knee.

What phase is FX201 in?

FX201 is currently in Phase 1 clinical development. It is an investigational drug and has not been approved by regulatory authorities. The ongoing Phase 1 trial is designed to evaluate the safety and tolerability of FX201 in patients with osteoarthritis of the knee.

What clinical trials is FX201 in?

FX201 is being studied in a Phase 1 clinical trial with the identifier NCT04119687, titled 'Study to Evaluate the Safety and Tolerability of FX201 in Patients with Osteoarthritis of the Knee.' This trial is active but not recruiting, with an enrollment of 72 participants in the United States.

Is FX201 a monoclonal antibody?

Yes, FX201 is a monoclonal antibody. It is being developed as a potential treatment for osteoarthritis of the knee. The drug is currently in Phase 1 clinical trials to assess its safety and tolerability in patients with this condition.