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MK0733, simvastatin

Phase 3

Hypercholesterolemia | Small molecule | Metabolic |Organon & Co.|Last Updated: Aug 15, 2024

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindUNCONTROLLED
Total Trials1
Total Enrollment571

FDA Designations

No designations recorded

Clinical trial landscape

MK0733, simvastatin · 1 trial · 1 indication

Phase 3 1
NCT00092157Effectiveness of Two Approved Drugs in Lowering High Cholesterol (0733-224)Hypercholesterolemia
COMPLETED571 Analytics
PHASE3COMPLETED
Effectiveness of Two Approved Drugs in Lowering High Cholesterol (0733-224)
HypercholesterolemiaUnlock trial analytics

Study Endpoints

Primary Endpoints

Fasting triglyceride levels at 12 weeks.

Secondary Endpoints

Total Cholesterol, LDL-C, HDL-C, VLDL-C, VLDL-TG, Apo A-I, and Apo B, CRP, PAI-1, fibrinogen, fasting plasma glucose, and fasting insulin
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT

Interventions

NameTypeDescription
MK0733, simvastatinDRUG -
Comparator: simvastatinDRUG -
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Eligibility Criteria

Age Range21 Years to 65 Years
SexALL
Healthy VolunteersNo

Inclusion Criteria: * Elevated cholesterol level Exclusion Criteria: * Liver disease * Known allergies to study drugs

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Frequently asked questions about MK0733, simvastatin

What is MK0733, simvastatin used for?

MK0733, simvastatin is a small molecule being studied for hypercholesterolemia and low HDL cholesterol. It is in Phase 3 clinical development for these metabolic conditions. The drug is investigational and not yet approved.

Who makes MK0733, simvastatin?

Organon & Co. (NYSE: OGN) is developing MK0733, simvastatin. The company is conducting Phase 3 clinical trials for the drug in hypercholesterolemia and HDL cholesterol.

What phase is MK0733, simvastatin in?

MK0733, simvastatin is in Phase 3 clinical development. It is an investigational drug being studied for hypercholesterolemia and low HDL cholesterol. It has not been approved by regulatory authorities.

What clinical trials is MK0733, simvastatin in?

MK0733, simvastatin has been studied in two completed Phase 3 trials. NCT00092157 enrolled 571 patients with hypercholesterolemia, and NCT00389896 enrolled 150 patients with type 2 diabetes to evaluate effects on HDL cholesterol. Both trials are completed.

Is MK0733, simvastatin the same as simvastatin?

Yes, MK0733, simvastatin is the same as simvastatin. The drug is referred to by both names in clinical trials. It is being developed by Organon & Co. for hypercholesterolemia and HDL cholesterol.