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CNP520

Phase 2

Alzheimer's Disease | Small molecule | Neurology |Novartis AG|Last Updated: Aug 11, 2017

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment124

FDA Designations

No designations recorded

Clinical trial landscape

CNP520 · 1 trial · 1 indication

Phase 2 1
NCT02576639Dose-ranging Safety and Tolerability Study in Subjects ≥60 Years of AgeAlzheimer's Disease
COMPLETED124 Analytics
PHASE2COMPLETED
Dose-ranging Safety and Tolerability Study in Subjects ≥60 Years of Age
Alzheimer's DiseaseUnlock trial analytics

Study Endpoints

Primary Endpoints

Number of Subjects With Non-serious and Serious Adverse Events (AEs) and Deaths
13 weeks

Safety monitoring was conducted throughout the study.

Secondary Endpoints

Change From Baseline of Amyloid Beta (Aβ) 1-38 , Aβ 1-40 and Aβ 1-42 Cerebrospinal Fluid (CSF) Concentrations
Day 92
Summary of Plasma PK Parameter: Cmax
Days 1, 91
Summary of Plasma PK Parameter: AUCtau
Days 1 and 91
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Study Design & Arms

AllocationRANDOMIZED
MaskingTRIPLE
ModelPARALLEL
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
PlaceboPLACEBO_COMPARATORMatching placebo to CNP520 was taken once daily (qd) orally for 13 weeks.
CNP520 2 mgEXPERIMENTALCNP520 2 mg was taken qd orally for 13 weeks.
CNP520 10 mgEXPERIMENTALCNP520 10 mg was taken qd orally for 13 weeks.
CNP520 35 mgEXPERIMENTALCNP520 35 mg was taken qd orally for 13 weeks.
CNP520 85 mgEXPERIMENTALCNP520 85 mg was taken qd orally for 13 weeks.

Interventions

NameTypeDescription
CNP520DRUG -
PlaceboDRUGMatching placebo to CNP520 was supplied in capsules.
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Eligibility Criteria

Age Range60 Years to 80 Years
SexALL
Healthy VolunteersYes
Study Sites11

Key Inclusion Criteria: * Healthy status * Body weight: ≥45kg * BMI: 18-34 kg/m2 Key Exclusion Criteria: * History or presence of any clinically significant disease of any major system organ class. * Heavy smoker status * History /presence of clinically significant neurological or psychiatric dis...

Countries:United StatesBelgiumGermanyNetherlandsUnited Kingdom
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Frequently asked questions about CNP520

What is CNP520 used for?

CNP520 is an investigational small molecule being studied for Alzheimer's disease. It is in Phase 2 clinical development and is intended for use in adults aged 60 years and older. The drug is being evaluated for its safety and tolerability in this population.

Who makes CNP520?

CNP520 is being developed by Novartis AG, a global pharmaceutical company traded on the New York Stock Exchange under the ticker symbol NVS. The company is conducting clinical trials to evaluate the drug's potential in Alzheimer's disease.

What phase is CNP520 in?

CNP520 is in Phase 2 clinical development. It is an investigational drug, meaning it has not been approved by regulatory authorities and is still being studied in clinical trials. The drug is being evaluated for safety and tolerability in patients with Alzheimer's disease.

What clinical trials is CNP520 in?

CNP520 has one completed Phase 2 clinical trial registered under NCT02576639. This was a dose-ranging safety and tolerability study in subjects aged 60 years and older, conducted in the United States, Belgium, Germany, Netherlands, and United Kingdom. The trial enrolled 124 participants.

Is CNP520 the same as any other drug?

CNP520 is a distinct investigational compound developed by Novartis AG. No alternative names for CNP520 have been reported in clinical trial registrations. It is being studied specifically for its potential role in Alzheimer's disease.