Recent Updates
Recently added Catalysts

GlucoNorm

Phase 2

Type 2 Diabetes | Small molecule | Metabolic |Novo Nordisk A/S|Last Updated: Jan 18, 2018

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
RandomizedCONTROLLEDBiomarker
Total Trials1
Total Enrollment30
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00451620Effect of GlucoNorm vs Glyburide on Post-Prandial Hyperglycemia in Elderly Subjects With Type 2 DiabetesPHASE2 COMPLETED 30Nov 1, 2003Sep 1, 2011Jan 18, 20181 Canada
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
The objective of this study is to determine whether GlucoNorm has a greater effect than Glyburide on insulin levels and postprandial glucose levels in elderly people with type 2 diabetes who are diet controlled.
2 hours
Unlock Study Endpoints
Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
2.EXPERIMENTALGlucoNorm
1.EXPERIMENTALGlyburide
Interventions
NameTypeDescription
glyburideDRUGSubjects will undergo 2 Standard Meal Tests with Ensure 325 ml separated by 15 - 30 days. Group 1 will receive GlucoNorm 1 mg during the 1st Standard Meal Test and Glyburide 2.5 mg during the 2nd Standard Meal Test. Group 2 will receive Glyburide 2.5 mg during the 1st Standard Meal Test and GlucoNorm 1mg during the 2nd Standard Meal Test.
GlucoNormDRUGSubjects will undergo 2 Standard Meal Tests with Ensure 325 ml separated by 15 - 30 days. Group 1 will receive GlucoNorm 1 mg during the 1st Standard Meal Test and Glyburide 2.5 mg during the 2nd Standard Meal Test. Group 2 will receive Glyburide 2.5 mg during the 1st Standard Meal Test and GlucoNorm 1mg during the 2nd Standard Meal Test.
Unlock Study Design Details
Eligibility Criteria
Age Range65 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Type 2 diabetes \> 3 months duration * Male or female * Over 65 years of age * Diet controlled only * HgbA1C \< 8.5% Exclusion Criteria: * Treatment with oral hypoglycemic agents or insulin or the likelihood of requiring treatment with these during the study. * Anemia - hgb ...

Countries:Canada
Unlock Eligibility Criteria