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MK0869, aprepitant

Phase 3

Major Depressive Disorder | Small molecule | Psychiatry |Merck & Company, Inc.|Trials Updated: May 5, 2017

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindUNCONTROLLED
Total Trials7
Total Enrollment4,418

FDA Designations

No designations recorded

MK0869, aprepitant clinical trials

MK0869, aprepitant · 7 trials · 5 indications

Phase 3 7
NCT000902462 Doses of an Approved Drug Being Studied for a New Indication for the Prevention of Postoperative Nausea and Vomiting (0869-091)Postoperative Nausea and Vomiting
COMPLETED922 Analytics
NCT000901552 Doses of an Approved Drug Being Studied for a New Indication for the Prevention of Postoperative Nausea and Vomiting (0869-090)(COMPLETED)Postoperative Nausea and Vomiting
COMPLETED805 Analytics
NCT00092196Study of MK0869 for the Prevention of Chemotherapy-Induced Nausea and Vomiting (0869-071)(COMPLETED)Nausea
COMPLETED820 Analytics
NCT00042029Treatment of Patients With Major Depressive Disorder With MK0869 (0869-073)Major Depressive Disorder
COMPLETED324 Analytics
NCT00034944Treatment of Patients With Major Depressive Disorder With MK0869 (0869-063)Major Depressive Disorder
COMPLETED495 Analytics
NCT00035295Treatment of Patients With Major Depressive Disorder With MK0869 (0869-061)Major Depressive Disorder
COMPLETED584 Analytics
NCT00035009Treatment of Patients With Major Depressive Disorder With MK0869 (0869-059)Major Depressive Disorder
COMPLETED468 Analytics
PHASE3COMPLETED
2 Doses of an Approved Drug Being Studied for a New Indication for the Prevention of Postoperative Nausea and Vomiting (0869-091)
Postoperative Nausea and VomitingUnlock trial analytics
PHASE3COMPLETED
2 Doses of an Approved Drug Being Studied for a New Indication for the Prevention of Postoperative Nausea and Vomiting (0869-090)(COMPLETED)
Postoperative Nausea and VomitingUnlock trial analytics
PHASE3COMPLETED
Study of MK0869 for the Prevention of Chemotherapy-Induced Nausea and Vomiting (0869-071)(COMPLETED)
NauseaUnlock trial analytics
PHASE3COMPLETED
Treatment of Patients With Major Depressive Disorder With MK0869 (0869-073)
Major Depressive DisorderUnlock trial analytics
PHASE3COMPLETED
Treatment of Patients With Major Depressive Disorder With MK0869 (0869-063)
Major Depressive DisorderUnlock trial analytics
PHASE3COMPLETED
Treatment of Patients With Major Depressive Disorder With MK0869 (0869-061)
Major Depressive DisorderUnlock trial analytics
PHASE3COMPLETED
Treatment of Patients With Major Depressive Disorder With MK0869 (0869-059)
Major Depressive DisorderUnlock trial analytics

Study Endpoints

Primary Endpoints

Prevention of PONV in the 24 hours following end of surgery; Tolerability
24 hours
Safety and tolerability
HAMD-17 total score; Tolerability
HAMD-17 total score at week 8. Tolerability.
Change from baseline in HAMD-17 total score at week 8. Mk-0869 will be generally well tolerated

Secondary Endpoints

Assessment of adverse experiences using the National Cancer Institute (NCI) criteria
CGI-I Scale score; Sheehan Disability Scale
CGI-I Scale score at week 8 and at least a 50% reduction in the HAMD-17 total score.
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposePREVENTION

Interventions

NameTypeDescription
MK0869, aprepitantDRUG -
Comparator: ondansetron IVDRUG -
MK0869, aprepitant / Duration of Treatment: 3 daysDRUG -
Comparator: placeboDRUG -
Comparator: paroxetine HCLDRUG -
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo

Inclusion Criteria: * Patient is at least 18 years of age. * Patient is scheduled to undergo open abdominal surgery requiring overnight hospital stay (24-hour hospital stay after end of surgery). * Patient is scheduled to receive general anesthesia. * Patient is scheduled to receive postoperative o...

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Frequently asked questions about MK0869, aprepitant

What is MK0869 (aprepitant) used for?

MK0869, also known as aprepitant, is a small molecule being studied for use in Major Depressive Disorder, Postoperative Nausea and Vomiting, and Nausea. It is developed by Merck & Company, Inc. and is currently in Phase 3 clinical development for these indications.

What does MK0869 target?

MK0869, also known as aprepitant, is a small molecule developed by Merck & Company, Inc. Its specific molecular target has not been disclosed in available clinical trial information. It is being investigated for psychiatric and nausea-related conditions.

Who makes MK0869?

MK0869, also known as aprepitant, is developed by Merck & Company, Inc., which trades under the ticker MRK. The drug is currently in Phase 3 clinical trials for Major Depressive Disorder, Postoperative Nausea and Vomiting, and Nausea.

What phase is MK0869 in?

MK0869, also known as aprepitant, is in Phase 3 clinical development. It is being studied for Major Depressive Disorder, Postoperative Nausea and Vomiting, and Nausea. All four completed trials were Phase 3, and the drug remains investigational for these uses.

What clinical trials is MK0869 in?

MK0869, also known as aprepitant, has completed four Phase 3 trials. These include NCT00035009 for Major Depressive Disorder, NCT00090155 and NCT00090246 for Postoperative Nausea and Vomiting, and NCT00092196 for chemotherapy-induced Nausea and Vomiting in breast neoplasms.

Is MK0869 the same as aprepitant?

Yes, MK0869 is the same as aprepitant. The drug is developed by Merck & Company, Inc. under the ticker MRK. It is being studied in Phase 3 trials for Major Depressive Disorder, Postoperative Nausea and Vomiting, and Nausea.