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BMS-986511

Phase 2

Major Depressive Disorder | Small molecule | Psychiatry |Bristol-Myers Squibb Company|Last Updated: Sep 4, 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindCONTROLLEDDMC
Total Trials1
Total Enrollment200

FDA Designations

No designations recorded

Clinical trial landscape

BMS-986511 · 1 trial · 1 indication

Phase 2 1
NCT07772531A Study to Evaluate BMS-986511 in Adults With Major Depressive DisorderMajor Depressive Disorder
NOT YET_RECRUITING200 Analytics
PHASE2NOT YET_RECRUITING
A Study to Evaluate BMS-986511 in Adults With Major Depressive Disorder
Major Depressive DisorderUnlock trial analytics

Study Endpoints

Primary Endpoints

Mean change from baseline in Hamilton Depression Rating Scale -17 Item (HDRS-17) total score
Up to Day 57

Secondary Endpoints

Number of Participants with Treatment Emergent Adverse Events (AEs)
Up to 71 days
Number of Participants with Serious Adverse Events (SAEs)
Up to 71 days
Number of Participants with AEs Leading to Treatment Discontinuation
Up to 71 days
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Study Design & Arms

AllocationRANDOMIZED
MaskingQUADRUPLE
ModelSEQUENTIAL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
BMS-986511: Dose AEXPERIMENTAL -
BMS-986511: Dose BEXPERIMENTAL -
PlaceboEXPERIMENTAL -

Interventions

NameTypeDescription
BMS-986511DRUGSpecified dose on specified days
PlaceboDRUGSpecified dose on specified days
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Eligibility Criteria

Age Range18 Years to 65 Years
SexALL
Healthy VolunteersNo
Study Sites27

Inclusion Criteria: * Participants must meet the MDD diagnosis per DSM-5 criteria confirmed by structured interview. * Participant must have current moderate to severe MDE confirmed by clinical assessment and validated scale. * Participant must have current MDE duration \>12 weeks at screening. * O...

Countries:United StatesCzechia
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Recent Changes (Last 90 Days)

LOWAug 20, 2026NCT07772531NEW_TRIAL: changed
LOWAug 20, 2026NCT07772531NEW_TRIAL: changed
LOWAug 20, 2026NCT07772531NEW_TRIAL: changed
LOWAug 20, 2026NCT07772531NEW_TRIAL: changed

Frequently asked questions about BMS-986511

What is BMS-986511 used for?

BMS-986511 is an investigational small molecule being developed for the treatment of Major Depressive Disorder (MDD) in adults. It is currently in Phase 2 clinical development and is not yet approved by regulatory authorities. The drug is being studied in a randomized, double-blind, controlled clinical trial.

Who makes BMS-986511?

BMS-986511 is being developed by Bristol-Myers Squibb Company, a biopharmaceutical company traded on the New York Stock Exchange under the ticker symbol BMY. The company is conducting a Phase 2 clinical trial of BMS-986511 in adults with Major Depressive Disorder.

What phase is BMS-986511 in?

BMS-986511 is in Phase 2 clinical development. It is an investigational drug and has not been approved by the FDA or any other regulatory agency. The ongoing Phase 2 trial is designed to evaluate the drug in adults with Major Depressive Disorder.

What clinical trials is BMS-986511 in?

BMS-986511 is being studied in a Phase 2 clinical trial registered as NCT07772531, titled "A Study to Evaluate BMS-986511 in Adults With Major Depressive Disorder." The trial is expected to enroll 200 participants in the United States and Czechia, and is currently not yet recruiting.

Is BMS-986511 FDA approved?

No, BMS-986511 is not FDA approved. It is an investigational drug currently in Phase 2 clinical development for Major Depressive Disorder. The drug has not completed clinical trials or received marketing authorization from the FDA or other regulatory bodies.