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MK0677

Phase 2

Alzheimer's Disease | Small molecule | Neurology |Merck & Company, Inc.|Last Updated: Jul 24, 2015

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindUNCONTROLLED
Total Trials1
Total Enrollment512
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00074529Study of MK0677 for the Treatment of Alzheimer's Disease (0677-030)(COMPLETED)PHASE2 COMPLETED 512Oct 1, 2003Jan 1, 2006Jul 24, 2015 -
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Study Endpoints
Primary Endpoints
Cognitive function over 12 month period; safety and tolerability
over 12 month period
Secondary Endpoints
AD symptoms over a 6 month and 12 month period measured by the CIBIC + and the ADAS-Cog.
over a 6 month and 12 month period
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
PurposeTREATMENT
Interventions
NameTypeDescription
MK0677DRUG -
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Eligibility Criteria
Age Range50 Years — N/A
SexALL
Healthy VolunteersNo

* Patients must have probable Alzheimer's disease of mild or moderate severity. * A brain scan and laboratory results must be consistent with Alzheimer's disease. * The patient must be otherwise medically healthy.

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