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LY3372993

Phase 1

Alzheimer Disease | Small molecule | Neurology |Eli Lilly and Company|Last Updated: Jun 17, 2026

Success Probability

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials2
Total Enrollment175

FDA Designations

No designations recorded

Clinical trial landscape

LY3372993 · 3 trials · 2 indications

Phase 1 3
NCT07346495A Study of Remternetug (LY3372993) in Healthy Chinese ParticipantsHealthy
ACTIVE NOT_RECRUITING24 Analytics
NCT04451408A Study of LY3372993 in Participants With Alzheimer's Disease (AD) and Healthy ParticipantsAlzheimer Disease
COMPLETED139 Analytics
NCT03720548A Study of LY3372993 in Healthy Participants and Participants With Alzheimer's Disease (AD)Alzheimer Disease
COMPLETED36 Analytics
PHASE1ACTIVE NOT_RECRUITING
A Study of Remternetug (LY3372993) in Healthy Chinese Participants
HealthyUnlock trial analytics
PHASE1COMPLETED
A Study of LY3372993 in Participants With Alzheimer's Disease (AD) and Healthy Participants
Alzheimer DiseaseUnlock trial analytics
PHASE1COMPLETED
A Study of LY3372993 in Healthy Participants and Participants With Alzheimer's Disease (AD)
Alzheimer DiseaseUnlock trial analytics

Study Endpoints

Primary Endpoints

Number of Participants with One or More Serious Adverse Event(s) (SAEs) Considered by the Investigator to be Related to Study Drug Administration
Baseline through study completion up to 25 weeks

Secondary Endpoints

Pharmacokinetics (PK): Maximum Observed Drug Concentration (Cmax) of Remternetug
Day 1 through Day 5
PK: Area Under the Concentration Versus Time Curve (AUC) of Remternetug
Day 1 through Day 5
Pharmacokinetics (PK): Maximum Concentration (Cmax) of LY3372993
Day 1 Predose through Week 61 (part A) and Week 13 (Part B)
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
RemternetugEXPERIMENTALRemternetug will be administered subcutaneously (SC)
PlaceboPLACEBO_COMPARATORPlacebo will be administered Subcutaneously (SC)
LY3372993 (Part A)EXPERIMENTALLY3372993 administered as multiple doses either intravenously (IV) or subcutaneously (SC).
LY3372993 (Part B)EXPERIMENTALLY3372993 administered as single dose IV or SC.
Placebo (Part A)PLACEBO_COMPARATORPlacebo administered as multiple doses IV or SC.
Placebo (Part B)PLACEBO_COMPARATORPlacebo administered as single dose IV or SC.

Interventions

NameTypeDescription
LY3372993DRUGAdministered SC
PlaceboDRUGAdministered SC
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Eligibility Criteria

Age Range18 Years to 45 Years
SexALL
Healthy VolunteersYes
Study Sites2

Inclusion Criteria: * Participants who are overtly healthy as determined by medical evaluation including medical history, physical examination, laboratory tests, electrocardiogram (ECG), and Magnetic resonance imaging (MRI). * Participants must be native Chinese. To qualify as Chinese for this stud...

Countries:ChinaUnited StatesJapan
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Recent Changes (Last 90 Days)

LOWJun 18, 2026NCT07346495Completion: 2027-01 → 2026-08
LOWJun 18, 2026NCT07346495Completion: 2027-01 → 2026-08
LOWJun 18, 2026NCT07346495Completion: 2027-01 → 2026-08
LOWJun 18, 2026NCT07346495Completion: 2027-01 → 2026-08

Frequently asked questions about LY3372993

What is LY3372993 used for?

LY3372993 is an investigational small molecule being studied for Alzheimer's disease. It is also being evaluated in healthy participants to assess its safety and tolerability. The drug is in Phase 1 clinical development and is not yet approved by regulatory authorities.

What does LY3372993 target?

LY3372993 is a small molecule being developed for Alzheimer's disease. Its specific molecular target has not been disclosed in the available clinical trial information. The drug is currently in Phase 1 studies to evaluate its safety and how it is processed in the body.

Who makes LY3372993?

LY3372993 is being developed by Eli Lilly and Company, a pharmaceutical company listed on the stock exchange under the ticker symbol LLY. The drug is currently in Phase 1 clinical trials for Alzheimer's disease and in healthy participants.

What phase is LY3372993 in?

LY3372993 is in Phase 1 clinical development. It is an investigational drug and has not been approved by the FDA or any other regulatory agency. All completed and ongoing trials for LY3372993 are Phase 1 studies.

What clinical trials is LY3372993 in?

LY3372993 has been studied in three Phase 1 clinical trials. Two trials, NCT03720548 and NCT04451408, are completed and enrolled participants with Alzheimer's disease and healthy volunteers in the United States and Japan. A third trial, NCT07346495, is active but not recruiting healthy Chinese participants.

Is LY3372993 the same as Remternetug?

Yes, LY3372993 is also known as Remternetug. In clinical trial NCT07346495, the study is titled 'A Study of Remternetug (LY3372993) in Healthy Chinese Participants,' confirming that both names refer to the same investigational drug.