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JNJ-26481585

Phase 1

Lymphoma | Small molecule | Oncology |Johnson & Johnson|Trials Updated: Sep 17, 2012

JNJ-26481585 development status

Highest phase Phase 1
Registered trials 2 across 1 sponsor since May 2008

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLEDDMC
Total Trials1
Total Enrollment92

FDA Designations

No designations recorded

JNJ-26481585 clinical trials

JNJ-26481585 · 1 trial · 2 indications

Phase 1 1
NCT00677105A Safety and Dose-finding Study of JNJ-26481585 for Patients With Advanced Solid Malignancies and Lymphoma.Lymphoma
COMPLETED92 Analytics
PHASE1COMPLETED
A Safety and Dose-finding Study of JNJ-26481585 for Patients With Advanced Solid Malignancies and Lymphoma.
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Study Endpoints

Primary Endpoints

Determine the safety and the maximum tolerated dose of JNJ-26481585. Determine how JNJ-26481585 and its metabolite, JNJ-26395018, are absorbed, broken down and eliminated after oral administration

Secondary Endpoints

Investigate the effect of food on the absorption, break down and elimination of JNJ-26481585 and its metabolite, JNJ-26395018. Monitor the antitumor activity of JNJ-26481585.
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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Interventions

NameTypeDescription
JNJ-26481585DRUG -
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites6

Inclusion Criteria: * Confirmed solid malignancy or lymphoma that is metastatic or unresectable, and for which standard curative or palliative measures do not exist or are no longer effective * Performance status (based on the Eastern Cooperative Oncology Group assessments) of \<= 2 * Life expectan...

Countries:United Kingdom
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Competitive Landscape -Lymphoma 494 trials

Top 20 of 70 competitors

CompanyTickerTrialsLead PhaseDrugs
Regeneron Pharmaceuticals, Inc.REGN7PHASE3Odronextamab, REGN5837
Merck & Co., Inc.MRK22PHASE3Nemtabrutinib, Zilovertamab vedotin, Pembrolizumab Berahyaluronidase alfa, Pembrolizumab, MK-1045
Eli Lilly and CompanyLLY12PHASE3Pirtobrutinib, LY4152199, LY4584180
AstraZeneca PLCAZN20PHASE3Acalabrutinib, Surovatamig, AZD0486, AZD4512, AZD5492
Novartis AG Sponsored ADRNVS9PHASE3Tisagenlecleucel, Rapcabtagene autoleucel, PIT565, Tulmimetostat
Incyte CorporationINCY16PHASE3Tafasitamab, parsaclisib, Ruxolitinib
Gilead Sciences, Inc.GILD7PHASE3Axicabtagene Ciloleucel, KITE-753, KTE-X19, KITE-197, INT2104
AbbVie, Inc.ABBV14PHASE3Venetoclax, Epcoritamab, ABBV-319, ABBV-453, ABBV-525
Genmab A/S Sponsored ADRGMAB18PHASE3Epcoritamab
Johnson & JohnsonJNJ15PHASE3Ibrutinib, Bortezomib, JNJ-90009530, JNJ-80948543, JNJ-75348780
BeOne Medicines Ltd. Sponsored ADRONC21PHASE3Tacabrutideg, Zanubrutinib, Lenalidomide, Tislelizumab, Sonrotoclax
Bristol-Myers Squibb CompanyBMY19PHASE3Golcadomide, Lenalidomide, Lisocabtagene maraleucel, Nivolumab, CC-122
Pfizer Inc.PFE4PHASE3Brentuximab vedotin, Rituximab, Axitinib, Bosutinib, Crizotinib
Nurix Therapeutics, Inc.NRIX6PHASE3NX-5948, NX-1607, NX-2127
Grifols, S.A. Sponsored ADR Class BGRFS1PHASE3Xembify
ADC Therapeutics LtdADCT3PHASE3Loncastuximab tesirine
Cellectar Biosciences, Inc.CLRB3PHASE3Iopofosine I-131
HUTCHMED (China) Limited Sponsored ADRHCM2PHASE3HMPL-760
Nuvalent, Inc. Class ANUVL1PHASE3Neladalkib
Corvus Pharmaceuticals, Inc.CRVS2PHASE3Soquelitinib
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Frequently asked questions about JNJ-26481585

What is JNJ-26481585 used for?

JNJ-26481585 is an investigational small molecule being studied for the treatment of lymphoma and advanced solid malignancies. It is in Phase 1 clinical development, meaning it has not yet been approved by regulatory authorities and is still being evaluated for safety and dosing in clinical trials.

Who makes JNJ-26481585?

JNJ-26481585 is being developed by Johnson & Johnson, a company traded on the New York Stock Exchange under the ticker symbol JNJ. The drug is currently in Phase 1 clinical development for oncology indications, including lymphoma.

What phase is JNJ-26481585 in?

JNJ-26481585 is in Phase 1 clinical development. It is an investigational drug, meaning it has not been approved by regulatory agencies. A Phase 1 trial has been completed, and the drug remains under investigation for safety and dosing in patients with advanced solid malignancies and lymphoma.

What clinical trials is JNJ-26481585 in?

JNJ-26481585 has one completed clinical trial, identified as NCT00677105. This was a Phase 1, open-label, uncontrolled safety and dose-finding study conducted in the United Kingdom, enrolling 92 patients with advanced solid malignancies and lymphoma. The trial is no longer active.

Is JNJ-26481585 the same as any other drug?

JNJ-26481585 is the primary name for this investigational compound. No alternative names have been established in the available clinical trial data. It is a small molecule being studied for its potential use in oncology, specifically for lymphoma and advanced solid tumors.