Recent Updates
Recently added Catalysts

IPH5201+ durvalumab+ standard chemotherapy

Phase 2

Non Small Cell Lung Cancer | Small molecule | Oncology |Innate Pharma S.A.|Last Updated: Jun 17, 2026

Success Probability

Subscribe to view

Market & Valuation

Subscribe to view

Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment70

FDA Designations

No designations recorded

Clinical trial landscape

IPH5201+ durvalumab+ standard chemotherapy · 1 trial · 1 indication

Phase 2 1
NCT05742607IPH5201 and Durvalumab in Patients With Resectable Non-Small Cell Lung Cancer (MATISSE)Non Small Cell Lung Cancer
RECRUITING70 Analytics
PHASE2RECRUITING
IPH5201 and Durvalumab in Patients With Resectable Non-Small Cell Lung Cancer (MATISSE)
Non Small Cell Lung CancerUnlock trial analytics

Study Endpoints

Primary Endpoints

Pathological Complete Response (pCR)
16 weeks after the first dose of study intervention.

Number of patients with pathological Complete Response (pCR)

Adverse events (AEs) and serious adverse events (SAEs)
Until Day 90 after the last dose of study interventions.

Number of patients with adverse events (AEs) and serious adverse events (SAEs).

Secondary Endpoints

Event-Free Survival (EFS)
Up to approximately 2 years.
Disease Free Survival (DFS)
Up to approximately 2 years.
Surgical resection
Approximately 16 weeks after the first dose of study intervention.
Unlock Study Endpoints

Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
IPH5201 + durvalumab + standard chemotherapyEXPERIMENTALPatients will receive Neoadjuvant therapy with IPH5201 and durvalumab in addition to standard chemotherapy. In Cohort 1 only, following surgery, patients will receive adjuvant treatment with IPH5201 and durvalumab.

Interventions

NameTypeDescription
IPH5201 + durvalumab + standard chemotherapyDRUGPatients will receive Neoadjuvant therapy with IPH5201 and durvalumab in addition to standard chemotherapy. In Cohort 1 only, Following surgery, patients will receive adjuvant treatment with IPH5201 and durvalumab.
Unlock Study Design Details

Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites30

Inclusion criteria Patients are eligible to be included in the study only if all of the following criteria apply: 1. Capable of giving signed informed consent, which includes compliance with the requirements and restrictions listed in the Informed Consent Form (ICF) and in this protocol. 2. Provis...

Countries:United StatesFranceGreeceHungaryPoland
Unlock Eligibility Criteria

Competitive Landscape -Non-Small Cell Lung Cancer 389 trials (matched to "Non Small Cell Lung Cancer")

Recent Changes (Last 90 Days)

MEDIUMJun 18, 2026NCT05742607primaryCompletionDate: changed
MEDIUMJun 18, 2026NCT05742607primaryCompletionDate: changed
MEDIUMJun 18, 2026NCT05742607primaryCompletionDate: changed
MEDIUMJun 18, 2026NCT05742607primaryCompletionDate: changed

Frequently asked questions about IPH5201+ durvalumab+ standard chemotherapy

What is IPH5201 + durvalumab + standard chemotherapy used for?

IPH5201 + durvalumab + standard chemotherapy is an investigational combination being studied for the treatment of Non Small Cell Lung Cancer (NSCLC). It is currently in Phase 2 clinical development, specifically for patients with resectable non-small cell lung cancer, as part of the MATISSE trial.

Who is developing IPH5201 + durvalumab + standard chemotherapy?

IPH5201 + durvalumab + standard chemotherapy is being developed by Innate Pharma S.A., a biopharmaceutical company. The company's ticker symbol is IPHA. The combination is being evaluated in a Phase 2 clinical trial for Non Small Cell Lung Cancer.

What phase is IPH5201 + durvalumab + standard chemotherapy in?

IPH5201 + durvalumab + standard chemotherapy is in Phase 2 clinical development. It is an investigational combination therapy, meaning it has not been approved by regulatory authorities and is still being studied in clinical trials for Non Small Cell Lung Cancer.

What clinical trials is IPH5201 + durvalumab + standard chemotherapy in?

IPH5201 + durvalumab + standard chemotherapy is being studied in the MATISSE trial, registered as NCT05742607. This Phase 2 trial is recruiting patients with resectable Non Small Cell Lung Cancer and has an enrollment target of 70 participants across the United States, France, Greece, Hungary, and Poland.

Is IPH5201 + durvalumab + standard chemotherapy the same as IPH5201 + durvalumab + standard chemotherapy?

Yes, IPH5201 + durvalumab + standard chemotherapy is also known as IPH5201 + durvalumab + standard chemotherapy. These names refer to the same investigational combination therapy being developed by Innate Pharma for Non Small Cell Lung Cancer.