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AH110690

Phase 2

Alzheimer's Disease | Small molecule | Neurology |GE HealthCare Technologies Inc.|Last Updated: Dec 7, 2009

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment78

FDA Designations

No designations recorded

Clinical trial landscape

AH110690 · 1 trial · 2 indications

Phase 2 1
NCT00785759Brain Uptake and Safety With Probable Alzheimer's Disease, Amnestic Mild Cognitive Impairment and Healthy VolunteersAlzheimer's Disease
COMPLETED78 Analytics
PHASE2COMPLETED
Brain Uptake and Safety With Probable Alzheimer's Disease, Amnestic Mild Cognitive Impairment and Healthy Volunteers
Alzheimer's DiseaseUnlock trial analytics

Study Endpoints

Primary Endpoints

Examine the efficacy and determine visual assessment of raised [18F] brain uptake for separating subjects with probable Alzheimer's Disease from healthy volunteers and assigning amnestic mild cognitive impairment cases to an AD or HV category.
September 2008 - February 2009

Secondary Endpoints

Examine the efficacy and parameters of brain [18F] uptake for separating 25 subjects with probable AD from 25 HV, assigning 20 amnestic MCI cases to an AD or HV category by measuring ranges of regional cerebral to cerebellum tracer uptake ratios.
September 2008 - February 2009
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeDIAGNOSTIC

Interventions

NameTypeDescription
AH110690 (18F) InjectionDRUGAll subjects will receive an I.V. dose of \[18F\]AH110690 (less than 10 mg of total AH110690). The target activity of a single administration of \[18F\]AH110690 will be 185 MBq (equivalent to a dose of approximately 6 mSv).
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Eligibility Criteria

Age Range25 Years to N/A
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * The subject meets National Institute of Neurological and Communicative Disorders and Stroke; Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria for clinically probable AD and Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV)...

Countries:Norway
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Frequently asked questions about AH110690

What is AH110690 used for in Alzheimer's Disease?

AH110690 is an investigational small molecule being studied for use in Alzheimer's Disease. It has been evaluated in a Phase 2 clinical trial involving patients with probable Alzheimer's Disease and amnestic mild cognitive impairment, as well as healthy volunteers, to assess brain uptake and safety.

Who makes AH110690?

AH110690 is being developed by GE HealthCare Technologies Inc., which trades under the ticker GEHC. The company is conducting clinical research on this investigational small molecule for Alzheimer's Disease.

What phase is AH110690 in?

AH110690 is in Phase 2 clinical development. It has completed one Phase 2 trial, and it remains an investigational drug that is not yet approved. The completed trial enrolled 78 participants and was uncontrolled, meaning it did not use a control group.

What clinical trials is AH110690 in?

AH110690 has been studied in one clinical trial, identified as NCT00785759. This Phase 2 study, titled 'Brain Uptake and Safety With Probable Alzheimer's Disease, Amnestic Mild Cognitive Impairment and Healthy Volunteers,' was completed and enrolled 78 participants in Norway.

Is AH110690 the same as any other drug?

AH110690 is the primary name for this investigational drug. No alternative names have been reported for this compound in the available clinical trial information. It is a small molecule being developed for Alzheimer's Disease.