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PAN-301-1

Phase 1

Prostate Cancer | Monoclonal antibody | Oncology |Faeth Therapeutics, Inc. Common Stock|Last Updated: Nov 12, 2021

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLEDDMC
Total Trials1
Total Enrollment12

FDA Designations

No designations recorded

Clinical trial landscape

PAN-301-1 · 1 trial · 1 indication

Phase 1 1
NCT03120832Phase 1 Trial of PAN-301-1 (SNS-301) in Cancer PatientsProstate Cancer
COMPLETED12 Analytics
PHASE1COMPLETED
Phase 1 Trial of PAN-301-1 (SNS-301) in Cancer Patients
Prostate CancerUnlock trial analytics

Study Endpoints

Primary Endpoints

Safety Assessed by Development of Adverse Events and Dose-limiting Toxicity to Determine Maximum Tolerated Dose
Through the 21 day interval after the first dose of vaccine

Secondary Endpoints

Safety Assessed by Administration Site Reactions, Abnormal Laboratory Values and/or Adverse Events
Through study completion, an average of 3 months. Patients were able to continue on treatment with one patient receiving approximately 15 months of treatment.
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSEQUENTIAL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
PAN-301-1 (SNS-301) VaccineEXPERIMENTALPAN-301-1 vaccine is administered intradermally in 3 cohorts of patients in a dose escalation schema every 21 days

Interventions

NameTypeDescription
PAN-301-1BIOLOGICAL -
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Eligibility Criteria

Age Range21 Years to 85 Years
SexMALE
Healthy VolunteersNo
Study Sites4

Inclusion Criteria: 1. Signed and dated written Ethics Committee approved informed consent 2. Men aged 21 to 85 years with a histologic diagnosis of prostate cancer with a biochemical relapse following definitive local therapy (RP or radiation therapy) 3. Patients are not eligible or are unwilling ...

Countries:United States
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Competitive Landscape -Prostate Cancer 254 trials

Frequently asked questions about PAN-301-1

What is PAN-301-1 used for in prostate cancer?

PAN-301-1 is an investigational monoclonal antibody being studied for the treatment of prostate cancer. It is currently in clinical development and has not been approved by regulatory authorities. The drug is being evaluated in a Phase 1 clinical trial to assess its safety and tolerability in patients with prostate cancer.

What does PAN-301-1 target?

The specific molecular target of PAN-301-1 has not been disclosed in available information. As a monoclonal antibody, it is designed to bind to a specific antigen, but the exact target is not publicly detailed. Further research and clinical data may reveal the precise mechanism of action.

Who is developing PAN-301-1?

PAN-301-1 is being developed by Sensei Biotherapeutics, Inc., a biopharmaceutical company. The company is conducting clinical trials to evaluate the drug's potential in treating prostate cancer. Sensei Biotherapeutics is focused on advancing innovative immunotherapies for cancer patients.

What phase is PAN-301-1 in?

PAN-301-1 is in Phase 1 clinical development. A Phase 1 trial has been completed, involving 12 patients with prostate cancer. The drug is still investigational and has not received FDA approval. Further clinical studies would be needed to establish its safety and efficacy.

What clinical trials is PAN-301-1 in?

PAN-301-1 has been studied in a Phase 1 clinical trial registered as NCT03120832. This trial, titled 'Phase 1 Trial of PAN-301-1 (SNS-301) in Cancer Patients,' was conducted in the United States and has been completed. The study enrolled 12 male patients with prostate cancer, aged 21 years and older.

Is PAN-301-1 the same as SNS-301?

Yes, PAN-301-1 is also known as SNS-301. The clinical trial NCT03120832 refers to the drug as PAN-301-1 (SNS-301), indicating that both names are used interchangeably for the same investigational monoclonal antibody being developed for prostate cancer.