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VLS-01-203 BU

Phase 2

Treatment Resistant Depression | Small molecule | Psychiatry |AtaiBeckley Inc.|Last Updated: May 11, 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment142

FDA Designations

No designations recorded

Clinical trial landscape

VLS-01-203 BU · 1 trial · 1 indication

Phase 2 1
NCT06524830A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)Treatment Resistant Depression
RECRUITING142 Analytics
PHASE2RECRUITING
A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)
Treatment Resistant DepressionUnlock trial analytics

Study Endpoints

Primary Endpoints

Change from Baseline in Montgomery-Åsberg Depression Rating Scale (MADRS) total score
Baseline to Day 29

Secondary Endpoints

Change from Baseline in MADRS total score
Baseline to Day 43
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Study Design & Arms

AllocationRANDOMIZED
MaskingTRIPLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
VLS-01-BUEXPERIMENTAL -
VLS-01-BU PlaceboPLACEBO_COMPARATOR -

Interventions

NameTypeDescription
VLS-01-203 BUDRUGVLS-01 buccal transmucosal administration
VLS-01-BU PlaceboDRUGPlacebo buccal transmucosal administration
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Eligibility Criteria

Age Range18 Years to 65 Years
SexALL
Healthy VolunteersNo
Study Sites48

Inclusion Criteria: * Participant must be 18 to 65 years of age inclusive at the time of signing the Informed Consent. * Has a diagnosis of recurrent moderate or severe MDD without psychotic features or single- episode MDD with duration greater than or equal to 3 months without psychotic features a...

Countries:United StatesAustraliaCanadaUnited Kingdom
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Frequently asked questions about VLS-01-203 BU

What is VLS-01-203 BU used for?

VLS-01-203 BU is an investigational small molecule being developed for the treatment of Treatment Resistant Depression. It is currently in Phase 2 clinical development and is being studied in patients with this condition.

Who is developing VLS-01-203 BU?

VLS-01-203 BU is being developed by AtaiBeckley Inc., a biopharmaceutical company listed on the stock exchange under the ticker ATAI. The company is conducting clinical trials to evaluate the drug's efficacy and safety.

What phase is VLS-01-203 BU in?

VLS-01-203 BU is in Phase 2 clinical development. It is an investigational drug and has not yet been approved by regulatory authorities. The ongoing Phase 2 trial is designed to assess its efficacy, safety, and tolerability.

What clinical trials is VLS-01-203 BU in?

VLS-01-203 BU is being evaluated in a Phase 2 clinical trial with the identifier NCT06524830, known as the ELUMINA study. This randomized, double-blind, placebo-controlled trial is recruiting 142 participants with Treatment Resistant Depression across the United States, Australia, Canada, and the United Kingdom.

Is VLS-01-203 BU the same as VLS-01?

VLS-01-203 BU is a specific formulation of the drug VLS-01, delivered as a buccal film. The ongoing Phase 2 trial evaluates this buccal film formulation in patients with Treatment Resistant Depression.