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Baminercept alfa 1

Phase 2

Rheumatoid Arthritis | Monoclonal antibody | Immunology |Biogen Inc.|Last Updated: Jan 21, 2016

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDDMC
Total Trials1
Total Enrollment391
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00664716Assessment Of The Safety And Efficacy Of BG9924 In Rheumatoid Arthritis (RA) ParticipantsPHASE2 COMPLETED 391Jul 1, 2007Oct 1, 2008Jan 21, 20168 Argentina, Brazil +6
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Study Endpoints
Primary Endpoints
Evaluate efficacy of BG9924 in combination with methotrexate (MTX) in RA participants who have had an inadequate response to DMARD therapy
3 months
Secondary Endpoints
Assess the safety and tolerability of BG9924 in this participant population
3 months
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
PlaceboPLACEBO_COMPARATORsubcutaneous administration of placebo given for 12 weeks
One DoseEXPERIMENTALBG9924 - dosage level administered as per Biogen Idec protocol
Second DoseEXPERIMENTALBG9924 - dosage level administered as per Biogen Idec protocol
Third DoseEXPERIMENTALBG9924 - dosage level administered as per Biogen Idec protocol
Fourth DoseEXPERIMENTALBG9924 - dosage level administered as per Biogen Idec protocol
Fifth DoseEXPERIMENTALBG9924 - dosage level administered as per Biogen Idec protocol
Interventions
NameTypeDescription
Baminercept alfa 1BIOLOGICALexperimental - one dose level
PlaceboBIOLOGICALPlacebo comparator
Baminercept alfa 2BIOLOGICALexperimental - second dose level
Baminercept alfa 3BIOLOGICALexperimental - third dose level
Baminercept alfa 4BIOLOGICALexperimental - fourth dose level
Baminercept alfa 5BIOLOGICALexperimental - fifth dose level
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Eligibility Criteria
Age Range18 Years — 75 Years
SexALL
Healthy VolunteersNo
Study Sites8

Key Inclusion Criteria: * Diagnosis of RA (functional class I - III) * Stable dose of MTX * Inadequate response to at least one conventional DMARD therapy Key Exclusion Criteria: * Serious local infection or systemic infection * History (Hx) of recurrent infections requiring oral or parenteral an...

Countries:ArgentinaBrazilHungaryMexicoPolandRomaniaRussiaUnited Kingdom
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