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DS-1062a

Phase 2

Non-small Cell Lung Cancer | Small molecule | Oncology |AstraZeneca PLC|Last Updated: Mar 24, 2026

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLEDBiomarker
Total Trials1
Total Enrollment137

FDA Designations

No designations recorded

Clinical trial landscape

DS-1062a · 1 trial · 1 indication

Phase 2 1
NCT04484142Study of DS-1062a in Advanced or Metastatic Non-small Cell Lung Cancer With Actionable Genomic Alterations (TROPION-Lung05)Non-small Cell Lung Cancer
COMPLETED137 Analytics
PHASE2COMPLETED
Study of DS-1062a in Advanced or Metastatic Non-small Cell Lung Cancer With Actionable Genomic Alterations (TROPION-Lung05)
Non-small Cell Lung CancerUnlock trial analytics

Study Endpoints

Primary Endpoints

Percentage of Participants With Objective Response Rate (ORR) Based on Blinded Independent Central Review (BICR)
From baseline until disease progression, death, or other protocol defined reason, up to approximately 24 months.

ORR is defined as the proportion of participants with a best overall response of confirmed complete response (CR) or confirmed partial response (PR) per Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1.

Secondary Endpoints

Duration of Response (DOR)
From baseline up to approximately 24 months
Progression-free Survival (PFS)
From baseline up to approximately 24 months
Overall Survival (OS)
From baseline up to approximately 24 months
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
DS-1062a 6.0 mg/kgEXPERIMENTALParticipants will receive 6.0 mg/kg of DS-1062a

Interventions

NameTypeDescription
DS-1062aDRUGDS-1062a will be administered as an intravenous (IV) infusion once every 3 weeks
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites84

Inclusion Criteria: Participants eligible for inclusion in the study must meet all inclusion criteria for this study. * Sign and date the inform consent form (ICF) prior to the start of any study- specific qualification procedures. * Adults ≥18 years (if the legal age of consent is \>18 years old,...

Countries:United StatesFranceGermanyHungaryItalyJapanNetherlandsSouth KoreaSpainTaiwan
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Competitive Landscape -Non-Small Cell Lung Cancer 389 trials

Frequently asked questions about DS-1062a

What is DS-1062a used for?

DS-1062a is an investigational small molecule being studied for the treatment of non-small cell lung cancer (NSCLC). It is currently in Phase 2 clinical development and is not yet approved by regulatory authorities. The drug is being evaluated in patients with advanced or metastatic NSCLC who have actionable genomic alterations.

Who makes DS-1062a?

DS-1062a is being developed by AstraZeneca PLC, a biopharmaceutical company listed on the stock exchange under the ticker symbol AZN. The company is conducting clinical trials to evaluate the safety and efficacy of this investigational oncology drug.

What phase is DS-1062a in?

DS-1062a is currently in Phase 2 clinical development. It is an investigational drug, meaning it has not yet received regulatory approval and is still being studied in clinical trials. The drug is being evaluated for the treatment of non-small cell lung cancer.

What clinical trials is DS-1062a in?

DS-1062a has been studied in a Phase 2 clinical trial with the identifier NCT04484142, titled 'Study of DS-1062a in Advanced or Metastatic Non-small Cell Lung Cancer With Actionable Genomic Alterations (TROPION-Lung05)'. This trial enrolled 137 participants and has been completed.

Is DS-1062a the same as TROPION-Lung05?

No, DS-1062a is the drug being studied, while TROPION-Lung05 is the name of the clinical trial evaluating it. The trial, identified as NCT04484142, is a Phase 2 study that has been completed and enrolled 137 patients with non-small cell lung cancer.