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Autologous Genetically modified T cells, MAGEA10ᶜ⁷⁹⁶T

Phase 1

Non-Small Cell Lung Cancer | Monoclonal antibody | Oncology |Adaptimmune Therapeutics PLC Sponsored ADR|Last Updated: Dec 9, 2025

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLEDBiomarker
Total Trials1
Total Enrollment28

FDA Designations

No designations recorded

Clinical trial landscape

Autologous Genetically modified T cells, MAGEA10ᶜ⁷⁹⁶T · 1 trial · 2 indications

Phase 1 1
NCT02592577MAGE A10ᶜ⁷⁹⁶T for Advanced NSCLCNon-Small Cell Lung Cancer
COMPLETED28 Analytics
PHASE1COMPLETED
MAGE A10ᶜ⁷⁹⁶T for Advanced NSCLC
Non-Small Cell Lung CancerUnlock trial analytics

Study Endpoints

Primary Endpoints

Number of subjects with dose-limiting toxicity (DLT) and adverse events (AE), including serious adverse events (SAE)
24 months

Determine if treatment with autologous genetically modified T cells, (MAGE A10ᶜ⁷⁹⁶T ) is safe and tolerable through assessment of DLTs, AEs, including SAEs; laboratory assessments, including chemistry, hematology, and coagulation; cardiac and pulmonary assessments, including ECG and troponin.

Secondary Endpoints

Proportion of subjects with a confirmed Complete Response (CR) or Partial Response (PR)
24 months
Interval between the date of first T cell infusion dose and first documented evidence of CR or PR
24 months
Interval between the date of first documented evidence of CR or PR until first documented disease progression or death due to any cause
24 months
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Autologous Genetically modified T cells, MAGEA10ᶜ⁷⁹⁶TEXPERIMENTAL -

Interventions

NameTypeDescription
Autologous Genetically modified T cells, MAGEA10ᶜ⁷⁹⁶TBIOLOGICAL -
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites19

Key Inclusion Criteria: 1. Subject has histologically or cytologically confirmed diagnosis of advanced non-small cell lung cancer (stage IIIB or IV) or recurrent disease 2. Subject has received at least one line of prior therapy 3. Subjects with known epidermal growth factor receptor (EGFR) mutatio...

Countries:United StatesCanadaSpainUnited Kingdom
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Competitive Landscape -Non-Small Cell Lung Cancer 387 trials