Recent Updates
Recently added Catalysts

donepezil

Phase 2

Alzheimer's Disease | Small molecule | Neurology |AbbVie Inc.|Last Updated: Nov 19, 2014

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment438
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01527916Evaluate the Efficacy and Safety of ABT-126 in Subjects With Mild to Moderate Alzheimer's DiseasePHASE2 COMPLETED 438Feb 1, 2012Nov 1, 2013Nov 19, 201433 United States, Poland +4
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
Alzheimer's Disease Assessment Scale - cognitive subscale
Measurements up through 24 weeks
Secondary Endpoints
Alzheimer's Disease Cooperative Study - Activities of Daily Living (ADCS-ADL)
Measurements up through 24 weeks
Mini Mental Status Exam (MMSE)
Measurements up through 24 weeks
DEMentia Quality of Life (DEMQOL)
Measurements up through 24 weeks
Unlock Study Endpoints
Study Design & Arms
AllocationRANDOMIZED
MaskingTRIPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
sugar pillPLACEBO_COMPARATOR -
donepezilACTIVE_COMPARATOR -
ABT-126 Low DoseEXPERIMENTALlow dose
ABT-126 Middle DoseEXPERIMENTALmiddle dose
ABT-126 high doseEXPERIMENTALhigh dose
Interventions
NameTypeDescription
placeboDRUGPlacebo Comparator
donepezilDRUGActive Comparator
ABT-126DRUGlow dose, middle dose, high dose
Unlock Study Design Details
Eligibility Criteria
Age Range55 Years — 90 Years
SexALL
Healthy VolunteersNo
Study Sites33

Inclusion Criteria: * The subject and caregiver must voluntarily sign and date an informed consent. If the subject does not have the capacity to provide informed consent, full informed consent must be obtained from the subject's representative and assent must be obtained from the subject. * The sub...

Countries:United StatesPolandRussiaSouth AfricaUkraineUnited Kingdom
Unlock Eligibility Criteria