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Volociximab

Phase 2

Pancreatic Cancer | Small molecule | Oncology |AbbVie Inc.|Last Updated: Jan 30, 2013

Success Probability

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Market & Valuation

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Trial Design

CONTROLLED
Total Trials1
Total Enrollment40

FDA Designations

No designations recorded

Clinical trial landscape

Volociximab · 1 trial · 1 indication

Phase 2 1
NCT00401570A Study of Volociximab in Combination With Gemcitabine in Metastatic Pancreatic CancerPancreatic Cancer
COMPLETED40 Analytics
PHASE2COMPLETED
A Study of Volociximab in Combination With Gemcitabine in Metastatic Pancreatic Cancer
Pancreatic CancerUnlock trial analytics

Study Endpoints

Primary Endpoints

The proportion of patients, in each dose cohort, with a confirmed tumor response
Any time during the course of the trial (up to 104 weeks)

Secondary Endpoints

Duration of progression-free survival
During the course of the trial (up to 104 weeks)
Time to disease progression
During the course of the trial (up to 104 weeks)
Duration of overall survival
During the course of the trial (up to 104 weeks)
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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Cohort 1EXPERIMENTALVolociximab (10 mg/kg every other week (qowk)) and Gemcitabine
Cohort 2EXPERIMENTALVolociximab (15 mg/kg weekly (qwk)) and Gemcitabine

Interventions

NameTypeDescription
VolociximabDRUGVolociximab: 10 mg/kg or 15mg/kg every week or every other week (qowk) via IV infusion for up to 104 weeks.
GemcitabineDRUGGemcitabine: Standard chemotherapy regime at 1 g/m2 once per week for 3 weeks via IV infusion, followed by one week with no treatment
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites6

Inclusion Criteria: * Male or female, 18 years of age or older. * Histologically or cytologically confirmed metastatic adenocarcinoma of the pancreas. * May have received prior immunotherapy (including monoclonal antibodies) or vaccine therapies. * Measurable disease, according to RECIST criteria. ...

Countries:United StatesUnited Kingdom
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Competitive Landscape -Pancreatic Cancer 179 trials

Top 20 of 68 competitors

CompanyTickerTrialsLead PhaseDrugs
Revolution Medicines, Inc.RVMD9PHASE3RMC-6236, Gemcitabine, nab-paclitaxel, Irinotecan, Liposomal irinotecan
Arcus Biosciences, Inc.RCUS3PHASE3Quemliclustat, Nab-paclitaxel, Gemcitabine
Pfizer Inc.PFE7PHASE2tisotumab vedotin, pembrolizumab, carboplatin, cisplatin
AstraZeneca PLCAZN9PHASE2AZD0901, 5-Fluorouracil, Leucovorin, l-leucovorin, Irinotecan
AbbVie, Inc.ABBV4PHASE2TTX-030, nab-paclitaxel and gemcitabine, Nab-Paclitaxel and gemcitabine
AngioDynamics, Inc.ANGO2PHASE3Modified FOLFIRINOX Regimen
Bristol-Myers Squibb CompanyBMY4PHASE2Navlimetostat, Gemcitabine, Nab-paclitaxel
Immuneering Corp. Class AIMRX2PHASE3Atebimetinib, GnP, mGnP
RenovoRx, Inc.RNXT1PHASE3Gemcitabine, nab-paclitaxel
BioNTech SE Sponsored ADRBNTX2PHASE2Pumitamig, Nab-paclitaxel, Gemcitabine, mFOLFIRINOX
Veracyte, Inc.VCYT1PHASE3Tislelizumab
ArriVent BioPharma, Inc.AVBP3PHASE2JAB-21822
Merck & Co., Inc.MRK2PHASE2Belzutifan
Eli Lilly and CompanyLLY7PHASE1LY4101174
Exelixis, Inc.EXEL1PHASE2Zanzalintinib, Everolimus
Agenus Inc.AGEN4PHASE2AGEN1423, Botensilimab, Gemcitabine, Nab-paclitaxel
HUTCHMED (China) Limited Sponsored ADRHCM1PHASE2Surufatinib Combined With Camrelizumab, Nab-paclitaxel, and Gemcitabine, Nab-paclitaxel Plus Gemcitabine, Surufatinib with Nab-paclitaxel, and Gemcitabine
Incyte CorporationINCY3PHASE2Ruxolitinib, Capecitabine, Regorafenib
Jazz Pharmaceuticals Public Limited CompanyJAZZ1PHASE2Zanidatamab
ImmunityBio IncIBRX1PHASE2N-803, Aldoxorubicin, PD-L1 t-haNK, Nab-paclitaxel, Gemcitabine
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Frequently asked questions about Volociximab

What is Volociximab used for in pancreatic cancer?

Volociximab is an investigational small molecule being studied for the treatment of metastatic pancreatic cancer. It is administered in combination with gemcitabine. The drug is currently in Phase 2 clinical development and is not yet approved by regulatory authorities.

Who is developing Volociximab?

Volociximab is being developed by AbbVie Inc., a biopharmaceutical company traded on the New York Stock Exchange under the ticker ABBV. The company is conducting clinical research to evaluate the drug's safety and efficacy in patients with pancreatic cancer.

What phase is Volociximab in?

Volociximab is in Phase 2 clinical development for the treatment of metastatic pancreatic cancer. It is an investigational drug, meaning it has not been approved for commercial use. The Phase 2 trial has been completed, and the drug remains under evaluation.

What clinical trials has Volociximab been in?

Volociximab has been studied in one clinical trial, identified as NCT00401570. This Phase 2 study evaluated the drug in combination with gemcitabine in patients with metastatic pancreatic cancer. The trial was completed and enrolled 40 participants in the United States and United Kingdom.

Is Volociximab a small molecule drug?

Yes, Volociximab is a small molecule drug. It is being investigated as a therapeutic option for pancreatic cancer, specifically in combination with gemcitabine. The drug is in Phase 2 clinical development and is not yet approved for patient use.