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Nab-paclitaxel Plus Gemcitabine

Phase 2

Metastatic Pancreatic Cancer | Small molecule | Oncology |HUTCHMED (China) Limited|Last Updated: May 28, 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedACTIVE_CONTROLLEDDMC
Total Trials1
Total Enrollment502

FDA Designations

No designations recorded

Clinical trial landscape

Nab-paclitaxel Plus Gemcitabine · 1 trial · 1 indication

Phase 2 1
NCT06361888A Phase II/III Trial to Evaluate the Efficacy and Safety of Surufatinib Combined With Camrelizumab, Nab-paclitaxel, and Gemcitabine in Metastatic Pancreatic CancerMetastatic Pancreatic Cancer
RECRUITING502 Analytics
PHASE2RECRUITING
A Phase II/III Trial to Evaluate the Efficacy and Safety of Surufatinib Combined With Camrelizumab, Nab-paclitaxel, and Gemcitabine in Metastatic Pancreatic Cancer
Metastatic Pancreatic CancerUnlock trial analytics

Study Endpoints

Primary Endpoints

Overall Survival (OS)
From date of first dose of study drug until withdrawal of consent or death (up to approximately 20 months)

Duration from the date of initial treatment to the date of death due to any cause

Secondary Endpoints

Progression-free Survival (PFS) (RECIST1.1)
From date of first dose of study drug until disease progression, withdrawal of consent, death, new anticancer therapy (up to approximately 20 months)
Objective response rate (ORR)(RECIST1.1)
From date of first dose of study drug until disease progression, withdrawal of consent, death, new anticancer therapy (up to approximately 20 months)
Duration of response (DoR)(RECIST1.1)
From date of first dose of study drug until disease progression, withdrawal of consent, death, new anticancer therapy (up to approximately 20 months)
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Study Design & Arms

AllocationRANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Surufatinib Combined With Camrelizumab, Nab-paclitaxel, and GemcitabineEXPERIMENTAL -
Nab-paclitaxel Plus GemcitabineACTIVE_COMPARATOR -
Surufatinib with Nab-paclitaxel, and GemcitabineOTHER -

Interventions

NameTypeDescription
Surufatinib Combined With Camrelizumab, Nab-paclitaxel, and GemcitabineDRUGDrug: Surufatinib Combined With Camrelizumab, Nab-paclitaxel, and Gemcitabine 1. Surufatinib: 200mg, qd 2. Camrelizumab: 200mg, IV drip, Q3W, D1 3. Nab-paclitaxel: 125 mg/m2, IV drip, D1,D8 4. Gemcitabine : 1000 mg/m2, IV drip, D1, D8
Nab-paclitaxel Plus GemcitabineDRUGDrug: Nab-paclitaxel Plus Gemcitabine 1. Nab-paclitaxel: 125 mg/m2, IV drip, D1,D8 2. Gemcitabine : 1000 mg/m2, IV drip, D1, D8
Surufatinib with Nab-paclitaxel, and GemcitabineDRUGDrug: Surufatinib with Nab-paclitaxel, and Gemcitabine 1. Surufatinib: 200mg, qd 2. Nab-paclitaxel: 125 mg/m2, IV drip, D1,D8 3. Gemcitabine : 1000 mg/m2, IV drip, D1, D8
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Eligibility Criteria

Age Range18 Years to 75 Years
SexALL
Healthy VolunteersNo
Study Sites2

Inclusion Criteria: 1. Fully understand and voluntarily sign an informed consent form, willing and able to follow the study process; 2. Age range is 18-75 years old (inclusive); 3. Pancreatic cancer confirmed by histology or cytology; 4. Stage IV metastasis Pancreatic cancer patients; 5. Have not r...

Countries:China
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Competitive Landscape -Pancreatic Cancer 178 trials (matched to "Metastatic Pancreatic Cancer")

Top 20 of 67 competitors

CompanyTickerTrialsLead PhaseDrugs
Revolution Medicines, Inc.RVMD9PHASE3RMC-6236, Gemcitabine, nab-paclitaxel, Irinotecan, Liposomal irinotecan
Arcus Biosciences, Inc.RCUS3PHASE3Quemliclustat, Nab-paclitaxel, Gemcitabine
Pfizer Inc.PFE7PHASE2tisotumab vedotin, pembrolizumab, carboplatin, cisplatin
AstraZeneca PLCAZN9PHASE2AZD0901, 5-Fluorouracil, Leucovorin, l-leucovorin, Irinotecan
AbbVie, Inc.ABBV4PHASE2TTX-030, nab-paclitaxel and gemcitabine, Nab-Paclitaxel and gemcitabine
AngioDynamics, Inc.ANGO2PHASE3Modified FOLFIRINOX Regimen
Bristol-Myers Squibb CompanyBMY4PHASE2Navlimetostat, Gemcitabine, Nab-paclitaxel
Immuneering Corp. Class AIMRX2PHASE3Atebimetinib, GnP, mGnP
RenovoRx, Inc.RNXT1PHASE3Gemcitabine, nab-paclitaxel
BioNTech SE Sponsored ADRBNTX2PHASE2Pumitamig, Nab-paclitaxel, Gemcitabine, mFOLFIRINOX
Veracyte, Inc.VCYT1PHASE3Tislelizumab
ArriVent BioPharma, Inc.AVBP3PHASE2JAB-21822
Merck & Co., Inc.MRK2PHASE2Belzutifan
Eli Lilly and CompanyLLY7PHASE1LY4101174
Exelixis, Inc.EXEL1PHASE2Zanzalintinib, Everolimus
Agenus Inc.AGEN4PHASE2AGEN1423, Botensilimab, Gemcitabine, Nab-paclitaxel
HUTCHMED (China) Limited Sponsored ADRHCM1PHASE2Surufatinib Combined With Camrelizumab, Nab-paclitaxel, and Gemcitabine, Nab-paclitaxel Plus Gemcitabine, Surufatinib with Nab-paclitaxel, and Gemcitabine
Incyte CorporationINCY3PHASE2Ruxolitinib, Capecitabine, Regorafenib
Jazz Pharmaceuticals Public Limited CompanyJAZZ1PHASE2Zanidatamab
ImmunityBio IncIBRX1PHASE2N-803, Aldoxorubicin, PD-L1 t-haNK, Nab-paclitaxel, Gemcitabine
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Frequently asked questions about Nab-paclitaxel Plus Gemcitabine

What is Nab-paclitaxel Plus Gemcitabine used for in metastatic pancreatic cancer?

Nab-paclitaxel Plus Gemcitabine is a combination regimen being studied for the treatment of metastatic pancreatic cancer. It is part of an investigational therapy that also includes surufatinib and camrelizumab. The regimen is currently being evaluated in a Phase II/III clinical trial in China.

Who is developing Nab-paclitaxel Plus Gemcitabine?

Nab-paclitaxel Plus Gemcitabine is being developed by HUTCHMED (China) Limited, a biopharmaceutical company listed on the stock exchange under the ticker HCM. The company is conducting a clinical trial of this combination regimen for metastatic pancreatic cancer.

What phase is Nab-paclitaxel Plus Gemcitabine in?

Nab-paclitaxel Plus Gemcitabine is in Phase 2 of clinical development. It is being studied in a Phase II/III trial, and the trial is currently recruiting participants. The drug combination is investigational and has not been approved for use.

What clinical trials is Nab-paclitaxel Plus Gemcitabine in?

Nab-paclitaxel Plus Gemcitabine is being studied in a single clinical trial with the identifier NCT06361888. This Phase II/III trial evaluates the efficacy and safety of surufatinib combined with camrelizumab, nab-paclitaxel, and gemcitabine in metastatic pancreatic cancer. The trial is recruiting 502 participants in China.

Is Nab-paclitaxel Plus Gemcitabine the same as surufatinib combined with camrelizumab?

Nab-paclitaxel Plus Gemcitabine is a component of the combination therapy being tested in the clinical trial NCT06361888. The full regimen includes surufatinib, camrelizumab, nab-paclitaxel, and gemcitabine. Nab-paclitaxel and gemcitabine are the chemotherapy backbone of this investigational combination.