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ALIA-1758

Phase 1

Alzheimer Disease | Small molecule | Neurology |AbbVie Inc.|Last Updated: Jul 17, 2025

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment53

FDA Designations

No designations recorded

Clinical trial landscape

ALIA-1758 · 1 trial · 1 indication

Phase 1 1
NCT06406348A Phase 1 Trial to Assess Safety, Tolerability and Pharmacokinetics of ALIA-1758 in Healthy ParticipantsAlzheimer Disease
COMPLETED53 Analytics
PHASE1COMPLETED
A Phase 1 Trial to Assess Safety, Tolerability and Pharmacokinetics of ALIA-1758 in Healthy Participants
Alzheimer DiseaseUnlock trial analytics

Study Endpoints

Primary Endpoints

Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability]
Up to 85 days after dosing

Incidence, severity, seriousness, and causality of treatment-emergent adverse events (TEAEs)

Secondary Endpoints

Pharmacokinetic parameters of ALIA-1758 in healthy subjects: Cmax
0-85 days after dosing
Pharmacokinetic parameters of ALIA-1758 in healthy subjects: T1/2
0-85 days after dosing
Pharmacokinetic parameters of ALIA-1758 in healthy subjects: AUC
0-85 days after dosing
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Study Design & Arms

AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
ActiveEXPERIMENTALSingle Ascending Dose (SAD) cohorts
PlaceboPLACEBO_COMPARATORSingle Ascending Dose (SAD) cohorts

Interventions

NameTypeDescription
ALIA-1758DRUGIntravenous or subcutaneous doses
PlaceboOTHERIntravenous or subcutaneous doses
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Eligibility Criteria

Age Range18 Years to 40 Years
SexALL
Healthy VolunteersYes
Study Sites1

Key Inclusion Criteria: * Participants must understand the nature of the trial and must provide signed and dated written informed consent in accordance with local regulations before the conduct of any trial-related procedures. * Healthy as determined by the Investigator, based on a medical evaluati...

Countries:United States
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Frequently asked questions about ALIA-1758

What is ALIA-1758 used for?

ALIA-1758 is an investigational small molecule being developed for the treatment of Alzheimer Disease. It is currently in Phase 1 clinical development and has not been approved by regulatory authorities. The drug is being studied to assess its safety, tolerability, and pharmacokinetics in healthy participants.

Who makes ALIA-1758?

ALIA-1758 is being developed by AbbVie Inc., a biopharmaceutical company traded on the New York Stock Exchange under the ticker symbol ABBV. The company is conducting clinical trials to evaluate the drug's safety and pharmacokinetic profile in healthy volunteers.

What phase is ALIA-1758 in?

ALIA-1758 is in Phase 1 clinical development. A Phase 1 trial has been completed, which evaluated the safety, tolerability, and pharmacokinetics of the drug in healthy participants. The drug remains investigational and is not yet approved for any use.

What clinical trials is ALIA-1758 in?

ALIA-1758 has one completed clinical trial registered as NCT06406348, titled "A Phase 1 Trial to Assess Safety, Tolerability and Pharmacokinetics of ALIA-1758 in Healthy Participants." The trial enrolled 53 participants in the United States and was a randomized, double-blind, placebo-controlled study.

Is ALIA-1758 FDA approved?

ALIA-1758 is not FDA approved. It is an investigational drug currently in Phase 1 clinical development. A Phase 1 trial has been completed to evaluate its safety and pharmacokinetics in healthy participants, but the drug has not yet received regulatory approval for the treatment of Alzheimer Disease.