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Rehabilitation · 1 trial · 1 indication
15-item, dichotomously scored measure of mobility disability. Fourteen items are self-report and one (standing for 10s without aids) is scored by observation
Objective measure of mobility, balance and locomotor performance, in which the individual is observed and timed rising from a chair, walking 3m, turning and returning to the chair
Identification by individual of up to five functional tasks that are important and difficult to perform, and rating of ability to perform each task on a 0-10 scale
Participants record the type of activity and its duration each day of the week (1-2 minutes per day to complete).
Worn by individual to assess physical activity behaviour over seven days. Should take 5 minutes to fit watch and 10 minutes to post back
| Arm | Type | Description |
|---|---|---|
| Rehabilitation training | EXPERIMENTAL | ReTrain: an exercise-based functional training programme comprising two phases: (1) weekly supervised sessions; (2) monthly drop-in sessions, plus home-based exercise in each phase. * Week 1: one-to-one consultations with trainer to introduce programme, assess individual's concerns and capabilities, introduce and negotiate initial goals * Weeks 2-11: bi-weekly 90 minute group class with group-based activities and one-to-one coaching, based on ongoing goal negotiation review and progression. * Week 12: one-to-one consultations with trainer to review goals and plan ongoing unsupervised exercise programme * Weeks 13-24: monthly drop-in sessions for one-to-one consultation, support and progression. |
| Control | NO_INTERVENTION | Control: treatment as usual plus receipt of a UK Stroke Association booklet on exercise after stroke. |
| Name | Type | Description |
|---|---|---|
| Rehabilitation | OTHER | ReTrain: an exercise-based functional training programme comprising two phases: (1) weekly supervised sessions; (2) monthly drop-in sessions, plus home-based exercise in each phase. * Week 1: one-to-one consultations with trainer to introduce programme, assess individual's concerns and capabilities, introduce and negotiate initial goals * Weeks 2-11: bi-weekly 90 minute group class with group-based activities and one-to-one coaching, based on ongoing goal negotiation review and progression. * Week 12: one-to-one consultations with trainer to review goals and plan ongoing unsupervised exercise programme * Weeks 13-24: monthly drop-in sessions for one-to-one consultation, support and progression. |
Inclusion Criteria: * Primary clinical diagnosis of stroke (assessed by referring clinician/GP records) * \>1 month (but no upper limit) since discharge from NHS physical rehabilitation services at randomisation * Able to walk independently indoors with or without mobility aids, but has self-report...
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Rehabilitation is an investigational therapy being studied for use in stroke patients. It is currently in Phase 1 clinical development, with one completed trial involving 48 participants in the United Kingdom. The therapy is being developed by United Therapeutics Corporation.
United Therapeutics Corporation (NASDAQ: UTHR) is developing Rehabilitation. The company is conducting clinical research on this therapy for stroke, with a Phase 1 trial that has been completed. The trial enrolled 48 participants in the United Kingdom.
Rehabilitation is in Phase 1 clinical development. A Phase 1 trial has been completed, and the therapy remains investigational. It has not been approved for use, and it is being studied for the treatment of stroke.
Rehabilitation has one completed clinical trial, NCT02429180, titled "Rehabilitation Training After Stroke." This Phase 1 study enrolled 48 participants with stroke in the United Kingdom. The trial was randomized and did not use a double-blind design.
Yes, the Phase 1 trial of Rehabilitation, NCT02429180, was randomized. The study enrolled 48 stroke patients and used a no-treatment control group. The trial was not double-blind and has been completed.