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JX10

Phase 2

Acute Ischemic Stroke | Small molecule | Neurology |Milestone Pharmaceuticals Inc.|Last Updated: Mar 13, 2026

Success Probability
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Market & Valuation
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment740
FDA Designations
No designations recorded
Clinical trial landscape

JX10 · 1 trial · 1 indication

Phase 2 1
NCT06990867Optimizing Reperfusion to Improve Outcomes and Neurologic FunctionAcute Ischemic Stroke
RECRUITING740 Analytics
PHASE2RECRUITING
Optimizing Reperfusion to Improve Outcomes and Neurologic Function
Acute Ischemic Stroke
NCT06990867740
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Study Endpoints
Primary Endpoints
Efficacy: Proportion of participants with no or minimal symptoms (mRS score 0-1) at 90 days
90 days
Safety: Incidence of symptomatic intracranial hemorrhage within 36 hours post-randomization
Within 36 hours post-randomization
Secondary Endpoints
Ordinal mRS score (0-6), based on a 6-point ordinal scale at 90 days
90 days
Proportion of participants with functional independence at 90 days
90 days
Incidence of adverse events (AEs) and serious adverse events (SAEs)
90 days
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Part 1 - JX10 (1mg/kg)EXPERIMENTAL -
Part 1 - JX10 (3mg/kg)EXPERIMENTAL -
Part 1 - PlaceboPLACEBO_COMPARATOR -
JX10 Part 2 - (1 or 3 mg/kg)EXPERIMENTAL -
Part 2 - PlaceboPLACEBO_COMPARATOR -
Interventions
NameTypeDescription
JX10DRUGJX10 is a thrombolytic agent.
PlaceboDRUGPlacebo is being used as the comparator.
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Eligibility Criteria
Age Range18 Years to 90 Years
SexALL
Healthy VolunteersNo
Study Sites83

Inclusion Criteria: 1. Age ≥ 18 and ≤ 90 years old. 2. Acute ischemic stroke with compatible clinical presentation and symptomatic high grade or complete occlusion of the intracranial internal carotid, M1, M2 or distal branches of the middle cerebral artery (MCA), anterior cerebral artery (ACA), or...

Countries:United StatesBelgiumBulgariaCanadaChinaFranceGermanyGreeceItalyJapanLatviaLithuaniaMalaysiaPortugalSerbiaSouth KoreaSpainThailand
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Recent Changes (Last 90 Days)
LOWMay 24, 2026NCT06990867studyFirstPostDate: changed