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AVE7688

Phase 2

Hypertension | Small molecule | Cardiovascular |Sanofi|Last Updated: May 18, 2016

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindCONTROLLED
Total Trials1
Total Enrollment1,940

FDA Designations

No designations recorded

Clinical trial landscape

AVE7688 · 1 trial · 1 indication

Phase 2 1
NCT00284128AVE7688 in Patients With Mild to Moderate Blood PressureHypertension
COMPLETED1,940 Analytics
PHASE2COMPLETED
AVE7688 in Patients With Mild to Moderate Blood Pressure
HypertensionUnlock trial analytics

Study Endpoints

Primary Endpoints

Change from baseline in trough diastolic blood pressure at the end of week 12.
12 weeks

Secondary Endpoints

Change from baseline in trough systolic blood pressure at the end of week 12, percentages of responders after 12 week of treatment.
12 weeks
Evaluation of long term safety and tolerability of AVE7688 with particular attention to angioedema.
12 months
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
ilepatril (2.5 mg ) once dailyEXPERIMENTALAVE7688 oral administration
ilepatril (10 mg) once dailyEXPERIMENTALAVE7688 oral administration
ilepatril (35 mg) once dailyEXPERIMENTALAVE7688 oral administration
ilepatril (50 mg) once dailyEXPERIMENTALAVE7688 oral administration
Losartan-potassium (100 mg) once dailyOTHERoral administration

Interventions

NameTypeDescription
AVE7688DRUGoral administration (capsules)
Losartan-potassiumDRUGoral administration (capsules)
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites21

Inclusion Criteria: * Patients with mild-to-moderate, treated or untreated, essential hypertension, as defined by the JNC VII (Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of High Blood Pressure, Seventh report ) guidelines who meet the following BP eligibility ...

Countries:United StatesArgentinaBrazilCanadaChileGermanyGreeceHong KongItalyMalaysiaMexicoNetherlandsPolandPortugalRussiaSingaporeSouth AfricaSouth KoreaSpainTaiwanTurkey (Türkiye)
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Frequently asked questions about AVE7688

What is AVE7688 used for?

AVE7688 is an investigational small molecule being developed for the treatment of hypertension, a cardiovascular condition characterized by elevated blood pressure. It is currently in Phase 2 clinical development.

Who is developing AVE7688?

AVE7688 is being developed by Sanofi, a global pharmaceutical company listed on the stock exchange under the ticker SNY. The drug is in Phase 2 clinical development for hypertension.

What phase is AVE7688 in?

AVE7688 is in Phase 2 clinical development. It has completed one Phase 2 trial, and it remains an investigational drug that has not been approved for commercial use.

What clinical trials is AVE7688 in?

AVE7688 has been studied in a completed Phase 2 clinical trial with the identifier NCT00284128. This trial enrolled 1,940 participants with mild to moderate hypertension and was conducted across multiple countries, including the United States, Brazil, Canada, and Germany.

Is AVE7688 the same as other blood pressure medications?

AVE7688 is a distinct investigational small molecule developed by Sanofi for hypertension. It is not known to be the same as any other marketed drug, and it is being evaluated specifically for its blood pressure-lowering effects in clinical trials.