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Ventricular Assist Device System

Phase 3

Heart Failure | Unknown | Cardiovascular |Rhythm Pharmaceuticals, Inc.|Last Updated: Oct 21, 2022

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment10

FDA Designations

No designations recorded

Clinical trial landscape

Ventricular Assist Device System · 1 trial · 1 indication

Phase 3 1
NCT03884504MDT-1118 Japan DT StudyHeart Failure
COMPLETED10 Analytics
PHASE3COMPLETED
MDT-1118 Japan DT Study
Heart FailureUnlock trial analytics

Study Endpoints

Primary Endpoints

Success at 12 months with the following definitions of success and failure
Implant to 12 months

Therapy will be considered a success if, at the end of 12 months in the study: 1. The subject is alive; and 2. The subject has not had a stroke of Modified Rankin Score ≥ 4; and 3. The subject retains the originally implanted device, unless the device was removed due to heart recovery, or the patient is electively transplanted. Therapy will be considered a failure if, within the 12 months in the study: 1. The subject dies; or 2. The subject has a stroke of Modified Rankin Score ≥ 4; or 3. The device malfunctions or fails, requiring exchange, explantation, or urgent transplantation.

Secondary Endpoints

Incidence of all adverse events per INTERMACS definition
Implant to 12 months
Incidence of all device malfunctions per INTERMACS definition
Implant to 12 months
Health Status improvement, as measured by KCCQ
Implant to 12 months
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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Interventions

NameTypeDescription
Ventricular Assist Device SystemDEVICEVentricular Assist Device System
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Eligibility Criteria

Age Range20 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: 1. Must be ≥20 years of age at consent 2. In judgment of body size, body surface area (BSA) and anatomy by Investigator, patient can be implanted MDT-1118 VAD. 3. Patients with advanced heart failure symptoms (Class IIIB or IV) who are: (patient must meet one of the following) ...

Countries:Japan
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Frequently asked questions about Ventricular Assist Device System

What is the Ventricular Assist Device System used for?

The Ventricular Assist Device System is used for heart failure. It is an investigational medical device being studied in patients with this condition. The system is currently in Phase 3 clinical development.

Who is developing the Ventricular Assist Device System?

Rhythm Pharmaceuticals, Inc. (NASDAQ: RYTM) is developing the Ventricular Assist Device System. The company is conducting clinical trials to evaluate the device for the treatment of heart failure.

What phase is the Ventricular Assist Device System in?

The Ventricular Assist Device System is in Phase 3 clinical development. It is an investigational device and has not been approved by regulatory authorities. A Phase 3 study has been completed to evaluate its use in heart failure.

What clinical trials is the Ventricular Assist Device System in?

The Ventricular Assist Device System has one completed Phase 3 clinical trial, NCT03884504, titled "MDT-1118 Japan DT Study." This study enrolled 10 participants with heart failure in Japan and included adults aged 20 years and older.

Is the Ventricular Assist Device System the same as MDT-1118?

The Ventricular Assist Device System is associated with the study device MDT-1118, as referenced in the clinical trial NCT03884504. The trial title "MDT-1118 Japan DT Study" indicates this device was evaluated in the Phase 3 study for heart failure.