Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
| NCT ID | Title | Phase | Status | Enrollment | Velocity | Design | Start | Completion | Last Updated | Sites | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|
| NCT00981357 | A Study To Investigate Whether PF-04457845 Is Effective In Treating Pain, Is Safe And Tolerable In Patients With Osteoarthritis Of The Knee | PHASE2 | COMPLETED | 76 | — | — | Nov 1, 2009 | May 1, 2010 | Sep 19, 2017 | 7 | United States, Canada +1 |
| Arm | Type | Description |
|---|---|---|
| PF-04457845 followed by placebo | EXPERIMENTAL | - |
| Placebo followed by PF-04457845 | EXPERIMENTAL | - |
| Naproxen followed by placebo | ACTIVE_COMPARATOR | - |
| Placebo followed by Naproxen | ACTIVE_COMPARATOR | - |
| Name | Type | Description |
|---|---|---|
| PF-04457845 | DRUG | PF-04457845 4 mg tablet once daily / matched placebo |
| Naproxen | DRUG | Naproxen 500 mg tablet twice daily / matched placebo |
Inclusion Criteria: * Subjects must have a diagnosis of Osteoarthritis (OA) of the knee confirmed by X-ray * Subjects must be willing and able to stop all current pain therapy for the duration of study. (Limited and specific pain therapy will be available throughout the study) * Subjects can be mal...