Recent Updates
Recently added Catalysts

salmon calcitonin, salmon calcitonin

Phase 1

Osteoarthritis | Small molecule | Musculoskeletal |Novartis AG|Last Updated: Jun 14, 2007

Target and mechanism

ModalitySmall molecule

Also known as Oral salmon calcitonin, salmon calcitonin nasal spray, Oral salmon calcitonin, salmon calcitonin

Success Probability

Subscribe to view

Market & Valuation

Subscribe to view

Trial Design

RandomizedDouble-BlindUNCONTROLLED
Total Trials1
Total Enrollment -

FDA Designations

No designations recorded

Clinical trial landscape

salmon calcitonin, salmon calcitonin · 3 trials · 2 indications

Phase 1 3
NCT00486317Pharmacokinetics/Pharmacodynamics of Oral Salmon Calcitonin in Patients With OsteoarthritisOsteoarthritis
COMPLETED- Analytics
NCT00395395Effects of Water and Food Intake on the Pharmacokinetics and Pharmacodynamics of Oral Salmon Calcitonin in Healthy Postmenopausal WomenPostmenopausal Osteoporosis
COMPLETED56 Analytics
NCT00411125Pharmacokinetics and Pharmacodynamics Study of Oral Salmon Calcitonin in Healthy Postmenopausal WomenPostmenopausal Osteoporosis
COMPLETED86 Analytics
PHASE1COMPLETED
Pharmacokinetics/Pharmacodynamics of Oral Salmon Calcitonin in Patients With Osteoarthritis
OsteoarthritisUnlock trial analytics
PHASE1COMPLETED
Effects of Water and Food Intake on the Pharmacokinetics and Pharmacodynamics of Oral Salmon Calcitonin in Healthy Postmenopausal Women
Postmenopausal OsteoporosisUnlock trial analytics
PHASE1COMPLETED
Pharmacokinetics and Pharmacodynamics Study of Oral Salmon Calcitonin in Healthy Postmenopausal Women
Postmenopausal OsteoporosisUnlock trial analytics

Study Endpoints

Primary Endpoints

Number of adverse events
Pharmacokinetic (PK) profile of oral salmon calcitonin taken in the morning with 50 ml or 200 ml water and at 10, 30 or 60 minutes before a meal
Pharmacokinetic profile of the new variant compared to the current variant on Day 1
Effect on bone resorption biomarker on Day 1

Secondary Endpoints

Changes in Urine CTX-I and CTX-II
Changes in serum osteocalcin
Pharmacodynamic (PD) profile of oral salmon calcitonin taken in the morning with 50 ml or 200 ml water and at 10, 30 or 60 minutes before a meal
Unlock Study Endpoints

Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT

Interventions

NameTypeDescription
Oral salmon calcitonin, salmon calcitonin nasal sprayDRUG -
Oral salmon calcitoninDRUG -
Unlock Study Design Details

Eligibility Criteria

Age Range52 Years to 75 Years
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Medical history and symptoms of knee osteoarthritis Exclusion Criteria: * Any other disease or medication affecting the bone or cartilage. * Any clinical signs or laboratory evidence diseases, which in the Investigator's opinion would preclude the participant from adhering t...

Countries:Denmark
Unlock Eligibility Criteria

Frequently asked questions about salmon calcitonin, salmon calcitonin

What is salmon calcitonin used for?

Salmon calcitonin is being studied for use in postmenopausal osteoporosis. It is an investigational small molecule in Phase 1 clinical development, evaluated in healthy postmenopausal women to understand its pharmacokinetics and pharmacodynamics. The drug is not approved and remains in clinical testing.

Who makes salmon calcitonin?

Salmon calcitonin is being developed by Novartis AG, traded on the New York Stock Exchange under the ticker NVS. The company is conducting clinical research on this investigational drug for postmenopausal osteoporosis.

What phase is salmon calcitonin in?

Salmon calcitonin is in Phase 1 clinical development. It is an investigational drug, not yet approved, and is being studied for postmenopausal osteoporosis. The Phase 1 trial has been completed.

What clinical trials is salmon calcitonin in?

Salmon calcitonin has one completed Phase 1 trial, NCT00411125, titled 'Pharmacokinetics and Pharmacodynamics Study of Oral Salmon Calcitonin in Healthy Postmenopausal Women.' The trial enrolled 86 female participants aged 40 years and older in Denmark.

Is salmon calcitonin a randomized controlled trial drug?

The Phase 1 trial of salmon calcitonin was randomized and double-blind, but it had an uncontrolled design, meaning there was no control group. The study was completed and enrolled 86 postmenopausal women.