Approval Probability
TA Base Rate
Adjusted LOA
ML Risk
Also known as Hydrochlorothiazide (HCTZ), Hydrochlorothiazide (HCTZ))
Hydrochlorothiazide · 1 trial · 1 indication
10 µl of acetylcholine (ACH) at 3 concentrations (10-7, 10-8, 10-9 M) was injected intra-dermally at 3 sites on the forearms. NaCl was injected at 2 sites on the forearms. Microcirculation was measured using laser doppler velocimetry before and 12 times in the 30 minutes following injection. The mean difference of the 12 post-injection measurements to the pre-injection measurement was calculated. Means for the 3 ACH and the 2 NaCl sites were calculated and compared. Microcirculation was measured in perfusion units which is an arbitrary measure specific to each laser doppler scanner.
| Arm | Type | Description |
|---|---|---|
| Valsartan followed by atenolol + hydrochlorothiazide (HCTZ) | EXPERIMENTAL | After a 2-week washout period, patients were treated with valsartan for 20 weeks followed by one week in which it was tapered off. Patients received valsartan 160 mg for 4 weeks, followed by valsartan 320 mg for 16 weeks. The valsartan dose was then tapered off to 80 mg for one week. Patients took valsartan film coated tablets orally once a day (od) in the morning. After a second 2-week washout period, patients were treated with atenolol plus HCTZ for 20 weeks. Patients received atenolol 100 mg for 20 weeks. Patients took atenolol tablets orally once a day (od) in the morning. Patients received HCTZ 12.5 mg for 4 weeks starting at the beginning of the 5th week and then received 25 mg for 12 weeks. Patients took HCTZ tablets orally once a day (od) in the morning. |
| Atenolol + hydrochlorothiazide (HCTZ) followed by valsartan | EXPERIMENTAL | After a 2-week washout period, patients were treated with atenolol plus HCTZ for 20 weeks followed by one week in which atenolol was tapered off and HCTZ was discontinued. Patients received atenolol 100 mg for 20 weeks. Patients took atenolol tablets orally once a day (od) in the morning. Patients received HCTZ 12.5 mg for 4 weeks starting at the beginning of the 5th week and then received 25 mg for 12 weeks. Patients took HCTZ tablets orally once a day (od) in the morning. After a second 2-week washout period, patients were treated with valsartan for 20 weeks. Patients received valsartan 160 mg for 4 weeks, followed by valsartan 320 mg for 16 weeks. Patients took valsartan film coated tablets orally once a day (od) in the morning. |
| Name | Type | Description |
|---|---|---|
| Atenolol | DRUG | 100 mg tablets orally once a day (od) in the morning. |
| Hydrochlorothiazide (HCTZ)) | DRUG | 12.5 or 25 mg tablets orally once a day (od) in the morning. |
| Valsartan | DRUG | 80 mg, 160 mg, or 320 mg tablets orally once a day in the morning |
Inclusion Criteria: * Caucasian; male or female outpatients and age between 40-65 years of age, inclusive. * At Visit 2 all patients must have a mean sitting diastolic blood pressure (msSBP) of ≥ 90 mmHg and \< 110 mmHg. Exclusion Criteria: * If a single reading for arterial hypertension in msSBP...