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Eplerenone Sandoz Inc., USA

Phase 1

Hypertension | Small molecule | Cardiovascular |Novartis AG|Last Updated: Mar 29, 2017

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLED
Total Trials2
Total Enrollment120
FDA Designations
No designations recorded
Clinical Trials (2)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00865176Comparative Bioavailability Study of Eplerenone 50 mg Tablets Under Fasting ConditionsPHASE1 COMPLETED 60Jun 1, 2006Jul 1, 2006Mar 29, 2017 -
NCT00865618Comparative Bioavailability Study of Eplerenone 50 mg Tablets Under Fed ConditionsPHASE1 COMPLETED 60Jun 1, 2006Jul 1, 2006Mar 29, 2017 -
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Study Endpoints
Primary Endpoints
Bioequivalence according to US FDA guidelines
10 days
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
1EXPERIMENTALEplerenone 50mg Tablets
2ACTIVE_COMPARATORINSPRA 50mg Tablets
Interventions
NameTypeDescription
Eplerenone 50 mg Tablets Sandoz Inc., USADRUG -
Inspra 50 mg Tablets GD Searle LLC, USADRUG -
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Eligibility Criteria
Age Range18 Years — 55 Years
SexALL
Healthy VolunteersYes

Inclusion Criteria: * No clinically significant abnormal finding on physical exam, medical history, or clinical laboratory results on screening. Exclusion Criteria: * Positive test results for HIV or hepatitis B or C. * Treatment for drug or alcohol dependence.

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