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Baroreceptor Stimulation · 1 trial · 1 indication
| Arm | Type | Description |
|---|---|---|
| Baroreceptor Stimulation | EXPERIMENTAL | - |
| Name | Type | Description |
|---|---|---|
| Baroreceptor Stimulation | DEVICE | The stimulation catheter may be placed in different locations within the IJV at the level of the cervical spine vertebrae. Stimulation amplitudes will be varied from 0.1 mA to 20 mA. |
Inclusion Criteria: * Subject is at least 18 years old * Subject is hypertensive (defined as at least one in-office Systolic BP measurement ≥140 mm Hg or Diastolic BP ≥90 mm Hg within three months prior to enrollment * Subject is undergoing a cardiac catheterization involving right heart catheteriz...
Baroreceptor Stimulation is an investigational therapy being studied for the treatment of hypertension, a condition of chronically elevated blood pressure. It is delivered through an endovascular approach that stimulates the carotid sinus, which is part of the body's blood pressure regulation system. The therapy is currently in early-stage clinical development.
Baroreceptor Stimulation is being developed by Medtronic plc, a medical technology company traded on the New York Stock Exchange under the ticker symbol MDT. Medtronic is conducting clinical research to evaluate the safety and effectiveness of this therapy for hypertension.
Baroreceptor Stimulation is in Phase 1 clinical development. It is an investigational therapy, meaning it has not been approved by regulatory authorities and is still being evaluated in clinical trials. The Phase 1 study has been completed, and the therapy remains in early-stage development for hypertension.
Baroreceptor Stimulation has one completed clinical trial registered under NCT01458483, titled "Acute Carotid Sinus Endovascular Stimulation II Study." This Phase 1 study enrolled 9 participants with hypertension in the United States. The trial was uncontrolled, meaning there was no comparison group, and it has been completed.
Baroreceptor Stimulation works by electrically stimulating the carotid sinus, which contains baroreceptors that sense blood pressure. This stimulation triggers a reflex that helps lower blood pressure. The therapy is delivered endovascularly, meaning through a catheter inserted into a blood vessel, targeting the carotid sinus area.