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DRM02

Phase 2

Psoriasis | Small molecule | Immunology |Eli Lilly and Company|Last Updated: Jul 20, 2021

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment23
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01993433A Safety and Efficacy Study of DRM02 in Subjects With Plaque PsoriasisPHASE2 COMPLETED 23Oct 1, 2013Mar 1, 2014Jul 20, 20212 Canada
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Study Endpoints
Primary Endpoints
Change in Physician's Lesion Assessment
Week 6
Secondary Endpoints
Physician's Lesion Assessment
From baseline to weeks 0, 1, 2, 3, 4 and 6
PLA dichotomized into "success" and "failure"
Week 6
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Study Design & Arms
AllocationRANDOMIZED
MaskingTRIPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
DRM02EXPERIMENTALDRM02 Topical Gel, 0.25%
VehiclePLACEBO_COMPARATORDRM02 Topical Gel, Vehicle
Interventions
NameTypeDescription
DRM02DRUG -
VehicleOTHER -
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Eligibility Criteria
Age Range18 Years — 70 Years
SexALL
Healthy VolunteersNo
Study Sites2

Inclusion Criteria: * Male or female 18 to 70 years of age. * Plaque-type psoriasis with two lesions of similar size and have an identical score of at least 6 but no more than 8 on the sum of the individual components of the Severity of Psoriasis Area Severity Index (PASI) at the Target Lesion scal...

Countries:Canada
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