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DRM02

Phase 2

Psoriasis | Small molecule | Dermatology |Eli Lilly and Company|Trials Updated: Jul 20, 2021

DRM02 development status

Highest phase Phase 2
Registered trials 2 across 1 sponsor since Nov 2001

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials2
Total Enrollment53

FDA Designations

No designations recorded

DRM02 clinical trials

DRM02 · 2 trials · 2 indications

Phase 2 2
NCT01993433A Safety and Efficacy Study of DRM02 in Subjects With Plaque PsoriasisPsoriasis
COMPLETED23 Analytics
NCT01993446A Safety and Efficacy Study of DRM02 in Subjects With RosaceaRosacea
COMPLETED30 Analytics
PHASE2COMPLETED
A Safety and Efficacy Study of DRM02 in Subjects With Plaque Psoriasis
PsoriasisUnlock trial analytics
PHASE2COMPLETED
A Safety and Efficacy Study of DRM02 in Subjects With Rosacea
RosaceaUnlock trial analytics

Study Endpoints

Primary Endpoints

Change in Physician's Lesion Assessment
Week 6
Change in inflammatory lesion count
Week 6

Secondary Endpoints

Physician's Lesion Assessment
From baseline to weeks 0, 1, 2, 3, 4 and 6
PLA dichotomized into "success" and "failure"
Week 6
Investigator's Global Evaluation (IGE)
From baseline to weeks 0, 1, 2, 3, 4 and 6
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Study Design & Arms

AllocationRANDOMIZED
MaskingTRIPLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
DRM02EXPERIMENTALDRM02 Topical Gel, 0.25%
VehiclePLACEBO_COMPARATORDRM02 Topical Gel, Vehicle

Interventions

NameTypeDescription
DRM02DRUG -
VehicleOTHER -
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Eligibility Criteria

Age Range18 Years to 70 Years
SexALL
Healthy VolunteersNo
Study Sites2

Inclusion Criteria: * Male or female 18 to 70 years of age. * Plaque-type psoriasis with two lesions of similar size and have an identical score of at least 6 but no more than 8 on the sum of the individual components of the Severity of Psoriasis Area Severity Index (PASI) at the Target Lesion scal...

Countries:Canada
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Frequently asked questions about DRM02

What is DRM02?

DRM02 is an investigational small molecule drug being developed by Eli Lilly and Company for dermatological conditions. It has been studied in Phase 2 clinical trials for plaque psoriasis and rosacea. DRM02 is not approved and remains in clinical development.

What is DRM02 used for?

DRM02 has been studied for the treatment of plaque psoriasis and rosacea, two inflammatory skin conditions. Both Phase 2 trials enrolled adults aged 18 years and older. The drug is investigational and has not been approved for any indication.

Who makes DRM02?

DRM02 is developed by Eli Lilly and Company, which trades on the New York Stock Exchange under the ticker LLY. Lilly is the sponsor of the clinical program evaluating DRM02 in dermatology indications.

What phase is DRM02 in?

DRM02 is in Phase 2 development. Two Phase 2 trials have been completed: one in rosacea and one in plaque psoriasis. The drug is investigational and has not received FDA approval for any indication.

What clinical trials is DRM02 in?

DRM02 has been evaluated in two completed Phase 2 trials. NCT01993446 studied DRM02 in 30 subjects with rosacea, and NCT01993433 studied it in 23 subjects with plaque psoriasis. Both were randomized, double-blind, placebo-controlled studies conducted in Canada.