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JNJ-77242113

Phase 3

Plaque Psoriasis | Small molecule | Dermatology |Johnson & Johnson|Last Updated: Jul 7, 2026

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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDDMC
Total Trials8
Total Enrollment3,824
FDA Designations
No designations recorded
Clinical trial landscape

JNJ-77242113 · 12 trials · 5 indications

Phase 3 6Phase 2 4Phase 1 2
NCT06934226A Study to Assess Efficacy and Safety of JNJ-77242113 Compared to Placebo and Ustekinumab in Participants With Moderate to Severe Plaque PsoriasisPlaque Psoriasis
ACTIVE NOT_RECRUITING752 Analytics
NCT06220604A Study of JNJ-77242113 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis (ICONIC-ADVANCE 2)Plaque Psoriasis
ACTIVE NOT_RECRUITING731 Analytics
NCT06295692A Study of JNJ-77242113 for the Treatment of Participants With Generalized Pustular Psoriasis or Erythrodermic PsoriasisGeneralized Pustular Psoriasis
ACTIVE NOT_RECRUITING19 Analytics
NCT06143878A Study of JNJ-77242113 for the Treatment of Participants With Moderate to Severe Plaque PsoriasisPlaque Psoriasis
ACTIVE NOT_RECRUITING774 Analytics
NCT06095102A Study of JNJ-77242113 for the Treatment of Participants With Plaque Psoriasis Involving Special Areas (Scalp, Genital, and/or Palms of the Hands and the Soles of the Feet)Plaque Psoriasis
ACTIVE NOT_RECRUITING311 Analytics
NCT06095115A Study of JNJ-77242113 in Adolescent and Adult Participants With Moderate to Severe Plaque PsoriasisPlaque Psoriasis
ACTIVE NOT_RECRUITING684 Analytics
PHASE3ACTIVE NOT_RECRUITING
A Study to Assess Efficacy and Safety of JNJ-77242113 Compared to Placebo and Ustekinumab in Participants With Moderate to Severe Plaque Psoriasis
Plaque PsoriasisUnlock trial analytics
PHASE3ACTIVE NOT_RECRUITING
A Study of JNJ-77242113 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis (ICONIC-ADVANCE 2)
Plaque PsoriasisUnlock trial analytics
PHASE3ACTIVE NOT_RECRUITING
A Study of JNJ-77242113 for the Treatment of Participants With Generalized Pustular Psoriasis or Erythrodermic Psoriasis
Generalized Pustular PsoriasisUnlock trial analytics
PHASE3ACTIVE NOT_RECRUITING
A Study of JNJ-77242113 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis
Plaque PsoriasisUnlock trial analytics
PHASE3ACTIVE NOT_RECRUITING
A Study of JNJ-77242113 for the Treatment of Participants With Plaque Psoriasis Involving Special Areas (Scalp, Genital, and/or Palms of the Hands and the Soles of the Feet)
Plaque PsoriasisUnlock trial analytics
PHASE3ACTIVE NOT_RECRUITING
A Study of JNJ-77242113 in Adolescent and Adult Participants With Moderate to Severe Plaque Psoriasis
Plaque PsoriasisUnlock trial analytics
Study Endpoints
Primary Endpoints
JNJ-77242113 and Placebo Group: Percentage of Participants with Investigator's Global Assessment (IGA) Score of 0 or 1 and Greater than or Equal to (>=) 2 Grade Improvement from Baseline at Week 16
Week 16

IGA score is given based on the investigator's assessment of the participant's plaque psoriasis at a given time point. Overall lesions are graded for induration, erythema, and scaling. The participant's plaque psoriasis is assessed as: cleared (0), minimal (1), mild (2), moderate (3), or severe (4).

JNJ-77242113 and Placebo Group: Percentage of Participants Achieving Psoriasis Area and Severity Index (PASI) 90 Response at Week 16
Week 16

PASI is a system used for assessing and grading the severity of psoriatic lesions and their response to therapy. In this system, the body is divided into 4 regions: the head, trunk, upper extremities, and lower extremities. Each of these areas is assessed and scored separately for erythema, induration, and scaling, which are each rated on a scale of 0 (none) to 4 (severe) and extent of involvement on a scale of 0 (indicates no involvement) to 6 (90% to 100% involvement). The PASI produces a numeric score that can range from 0 to 72. A higher score indicates more severe disease. A PASI 90 response represents participants achieving at least a 90 percent improvement from baseline in the PASI score.

Percentage of Participants Who Achieved an Investigator's Global Assessment (IGA) Score of 0 or 1 and Greater Than or Equal to (>=) 2-Grade Improvement From Baseline at Week 16
Week 16

IGA assesses participant's plaque psoriasis. Lesions were graded for induration, erythema and scaling, each using 5 point scale. Induration: 0 =no evidence of plaque elevation, 1=minimal plaque elevation,= 0.25 millimeters (mm); 2=mild plaque elevation,= 0.5 mm; 3=moderate plaque elevation,= 0.75 mm; 4=severe plaque elevation, greater than (\>) 1 mm; Erythema: 0=no evidence of erythema, hyperpigmentation may be present, 1=faint erythema, 2=light red coloration, 3=moderate red coloration, 4=bright red coloration; Scaling: 0=no evidence of scaling, 1=minimal; 2=mild; fine scale dominates, 3=moderate; coarse scale predominates, 4=severe; thick, scale predominates. Final IGA score of psoriasis was based upon average of induration, erythema and scaling scores assessed on 5 point scale: cleared (0), minimal (1), mild (2), moderate (3), or severe (4). Higher score=more severe disease. Baseline=closest measurement taken prior to or at the time of first study drug administration date.

Percentage of Participants Who Achieved Psoriasis Area and Severity Index (PASI) 90 Response at Week 16
Week 16

Percentage of participants who achieved PASI-90 score (\>=90% improvement from baseline in PASI) at Week 16 was reported. The PASI was a system used for assessing and grading the severity of psoriatic lesions and their response to therapy. In the PASI system, the body was divided into 4 regions: the head, trunk, upper extremities, and lower extremities. Each of these areas was assessed and scored separately for erythema, induration, and scaling, which were each rated on a scale of 0 to 4 (0 = none, 1 = slight, 2 = moderate, 3 = severe and 4 = very severe) and extent of involvement from 0 (indicated no involvement) to 6 (90% - 100% involvement). The PASI produced a numeric total score that could range from 0 (no psoriasis) to 72 (maximum psoriasis). Higher score indicated greater severity of psoriasis. The baseline was defined as the closest measurement taken prior to or at the time of the first study drug administration date.

Percentage of Participants With Generalized Pustular Psoriasis (GPP) Who Experienced Treatment Success at Week 16
Week 16

Percentage of participants with GPP who experienced treatment success at Week 16 was reported. Treatment success for GPP was defined as at least "minimally improved" rating in Clinical Global Impression (CGI) scale for GPP based on Japanese Dermatological Association (JDA) total score. JDA severity index includes skin symptoms (area of erythema with pustules, total area of erythema, and area of edema; each scored 0-3) and systemic/laboratory findings (fever, white blood cell count, C-reactive protein, and serum albumin; each scored 0-2). JDA total score was sum of 2 assessments ranging from 0 (best) to 17 (worst). CGI ratings were defined as: 1=Very much improved (greater than or equal to \[\>=\]3-point reduction in JDA total score), 2=Much improved (1-2-point reduction), 3=Minimally improved (no change in JDA total score, but \>=20 percent (%) reduction in area of erythema with pustules or meaningful improvement in \>=1 other parameter), 4=No change, 5=Worsened. Higher score = worsening.

Percentage of Participants With Erythrodermic Psoriasis (EP) Who Experience Treatment Success at Week 16
Week 16

Percentage of participants with EP who experienced treatment success at Week 16 was reported. Treatment success for EP was defined as at least "minimally improved" rating in CGI scale for EP. The CGI scale is a clinician-rated 5-point scale with the following categories: 1 = Very much improved, 2 = Much improved, 3 = Minimally improved, 4 = No change, 5 = Worsened. Higher score indicated worsening.

Percentage of Participants Who Achieved an Investigator's Global Assessment (IGA) Score of 0 or 1 and a Greater Than or Equal to (>=) 2-Grade Improvement From Baseline at Week 16
Week 16

IGA assesses participant's plaque psoriasis. Lesions were graded for induration, erythema, scaling, each using 5 point scale. Induration:0=no evidence of plaque elevation, 1=minimal plaque elevation,=0.25 millimeters(mm); 2=mild plaque elevation,=0.5 mm; 3=moderate plaque elevation,=0.75 mm; 4=severe plaque elevation,\>1 mm; Erythema: 0=no evidence of erythema, hyperpigmentation may be present, 1=faint erythema, 2=light red coloration, 3=moderate red coloration, 4=bright red coloration; Scaling: 0=no evidence of scaling, 1=minimal; occasional fine scale over less than 5% of lesion, 2=mild; fine scale dominates, 3=moderate; coarse scale predominates, 4=severe; thick, scale predominates. Final IGA score was based upon average of induration, erythema and scaling scores assessed on 5 point scale: cleared (0), minimal (1), mild (2), moderate (3), or severe(4). Higher score=more severe disease. Baseline=closest measurement taken prior to or at time of first study drug administration date.

Percentage of Participants Who Achieved Psoriasis Area and Severity Index (PASI) 90 at Week 16
Week 16

Percentage of participants who achieved PASI-90 score (\>=90% improvement from baseline in PASI) at Week 16 was reported. The PASI was a system used for assessing and grading the severity of psoriatic lesions and their response to therapy. In the PASI system, the body was divided into 4 regions: the head, trunk, upper extremities, and lower extremities. Each of these areas was assessed and scored separately for erythema, induration, and scaling, which were each rated on a scale of 0 to 4 (0 = none, 1 = slight, 2 = moderate, 3 = severe and 4 = very severe) and extent of involvement from 0 (indicated no involvement) to 6 (90% - 100% involvement). The PASI produced a numeric total score that could range from 0 (no psoriasis) to 72 (maximum psoriasis). Higher score indicated greater severity of psoriasis. The baseline was defined as the closest measurement taken prior to or at the time of the first study drug administration date.

Percentage of Participants with Clinical Response at Week 12
Week 12

Clinical response is defined as decrease from baseline in the modified Mayo score by greater than or equal to (\>=) 30 percent (%) and \>=2 points, with either a \>=1-point decrease from baseline in the rectal bleeding subscore or a rectal bleeding subscore of 0 or 1.

Percentages of Participants Who Achieved at Least 75 Percent (%) Improvement From Baseline in Psoriasis Area and Severity Index (PASI 75) Score at Week 16
Baseline (Week 0), Week 16

Percentage of participants who achieved PASI-75 score (greater than or equal to \[\>=\] 75% improvement from baseline in PASI) at Week 16 were reported. The PASI was a system used for assessing and grading the severity of psoriatic lesions and their response to therapy. In the PASI system, the body was divided into 4 regions: the head, trunk, upper extremities, and lower extremities. Each of these areas were assessed and scored separately for erythema, induration, and scaling, which were each rated on a scale of 0 to 4 (0=none, 1 = slight, 2 = moderate, 3 = severe and 4 = very severe) and extent of involvement from 0 (indicated no involvement) to 6 (90% - 100% involvement). The PASI produced a numeric total score that could range from 0 (no psoriasis) to 72 (maximum psoriasis). Higher score indicated greater severity of psoriasis. The baseline was defined as the closest measurement taken prior to or at the time of the first study drug administration date.

Percentage of Participants Who Achieved Greater Than or Equal to (>=) 75 Percent (%) Improvement From Baseline in Psoriasis Area Severity Index Score (PASI-75) at LTE Week 36
Baseline (Week 0 of originating study 77242113PSO2001), LTE Week 36 (52 weeks from originating study baseline)

Percentage of participants who achieved \>=75% improvement from baseline in PASI score at LTE Week 36 was reported. The PASI was a system used for assessing and grading the severity of psoriatic lesions and their response to therapy. In the PASI system, the body was divided into 4 regions: the head, trunk, upper extremities, and lower extremities. Each of these areas were assessed and scored separately for erythema, induration, and scaling, which were each rated on a scale of 0 to 4 (0=none, 1=slight, 2=moderate, 3=severe, 4=very severe) and extent of involvement from 0 (no involvement) to 6 (90% - 100% involvement). The PASI produced a numeric total score that could range from 0 (no psoriasis) to 72 (maximum psoriasis). Higher score indicated more severe disease. The baseline was defined as the closest measurement taken prior to or at the time of first study drug administration date in 77242113PSO2001 study.

Percentage of Participants Who Achieved at Least 75 Percent (%) Improvement From Baseline in Psoriasis Area and Severity Index (PASI-75) at Week 16
Baseline (Week 0), Week 16

Percentage of participants who achieved PASI-75 score (greater than or equal to \[\>=\] 75% improvement from baseline in PASI) at Week 16 was reported. The PASI was a system used for assessing and grading the severity of psoriatic lesions and their response to therapy. In the PASI system, the body was divided into 4 regions: the head, trunk, upper extremities, and lower extremities. Each of these areas were assessed and scored separately for erythema, induration, and scaling, which were each rated on a scale of 0 to 4 (0=none, 1 = slight, 2 = moderate, 3 = severe and 4 = very severe) and extent of involvement from 0 (indicated no involvement) to 6 (90% - 100% involvement). The PASI produced a numeric total score that could range from 0 (no psoriasis) to 72 (maximum psoriasis). Higher score indicated greater severity of psoriasis. The baseline was defined as the closest measurement taken prior to or at the time of the first study drug administration date.

Area Under the Plasma Concentration versus Time Curve From Time Zero to Time of the Last Measurable Concentration (AUC[0-last]) of JNJ-77242113
Predose up to Day 3

AUC(0-last) is defined as area under the plasma concentration versus time curve from time zero to time of the last measurable concentration of JNJ-77242113.

Area Under the Plasma Concentration versus Time Curve From Time Zero to Infinite Time (AUC[0-infinite]) of JNJ-77242113
Predose up to Day 3

AUC(0-infinite) is defined as area under the plasma concentration versus time curve from time zero to infinite time of JNJ-77242113.

Maximum Observed Plasma Concentration (Cmax) of JNJ-77242113
Predose up to Day 3

Cmax is defined as maximum observed plasma concentration of JNJ-77242113.

Time to Reach the Maximum Observed Plasma Concentration (Tmax) of JNJ-77242113
Predose up to Day 3

Tmax is defined as time to reach the maximum observed plasma concentration of JNJ-77242113.

Apparent Elimination Half-life (T1/2) of JNJ-77242113
Predose up to Day 3

T1/2 is defined as apparent elimination half-life associated with the terminal slope of the semilogarithmic drug concentration-time curve of JNJ-77242113.

Apparent Total Systemic Clearance (CL/F) of JNJ-77242113
Predose up to Day 3

CL/F is defined as apparent total systemic clearance after extravascular administration of JNJ-77242113.

Apparent Volume of Distribution (Vz/F) of JNJ-77242113
Predose up to Day 3

Vz/F is defined as apparent volume based on terminal phase after extravascular administration of distribution of JNJ-77242113.

Parts 1, 2 and 3: Number of Participants with Adverse Events (AEs) as a Measure of Safety and Tolerability
Up to 6 weeks

An AE is any untoward medical occurrence in a participant participating in a clinical study that does not necessarily have a causal relationship with the pharmaceutical/biological agent under study.

Parts 1, 2 and 3: Plasma Concentration of JNJ-77242113
Predose up to 48 hours postdose (Up to Day 3)

Plasma samples will be analyzed to determine concentrations of JNJ-77242113 using a validated, specific and sensitive method.

Secondary Endpoints
JNJ-77242113 and Placebo Group: Percentage of Participants Achieving PASI 75 Response at Week 16
Week 16
JNJ-77242113 and Placebo Group: Percentage of Participants Achieving PASI 100 Response at Week 16
Week 16
JNJ-77242113 and Placebo Group: Percentage of Participants with IGA Score of 0 at Week 16
Week 16
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Arm 1: JNJ 77242113EXPERIMENTALParticipants will receive JNJ-77242113 once daily from Week 0 through Week 104. All participant will receive ustekinumab matching placebo at Week 0, 4 and 16 to maintain the blind.
Arm 2: PlaceboPLACEBO_COMPARATORParticipants will receive matching placebo for JNJ-77242113 from Week 0 through Week 16, matching placebo for ustekinumab at Week 0, 4 and 16 and JNJ-77242113 from Week 16 through Week 104.
Arm 3: UstekinumabACTIVE_COMPARATORParticipants will receive Ustekinumab at Week 0, Week 4, and Week 16 followed by JNJ-77242113 once daily from Week 28 through Week 104. Participants will receive both Ustekinumab and placebo for JNJ-77242113 to maintain the blind through Week 28.
JNJ-77242113EXPERIMENTALParticipants will receive JNJ-77242113 from Week 0 through Week 156 and deucravacitinib matching placebo from Week 0 through Week 24.
PlaceboPLACEBO_COMPARATORParticipants will receive matching placebo for JNJ-77242113 from Week 0 through Week 16, matching placebo for deucravacitinib from Week 0 through Week 24 and JNJ-77242113 from Week 16 through Week 156.
DeucravacitinibACTIVE_COMPARATORParticipants will receive deucravacitinib from Week 0 through Week 24 and matching placebo for JNJ-77242113 from Week 0 through Week 24 and JNJ-77242113 from Week 24 through Week 156.
JNJ-77242113- Participants With Generalized Pustular Psoriasis (GPP) or Erythrodermic Psoriasis (EP)EXPERIMENTALParticipants with GPP or EP will receive JNJ-77242113 tablet orally.
Group 1: JNJ-77242113 Dose-1EXPERIMENTALParticipants will receive JNJ-77242113 Dose-1 tablets orally from Week 0 through Week 28. Participants who complete the Week 28 assessments and have achieved clinical response at Week 28 and who, in the opinion of the investigator, will continue to benefit from treatment with study intervention will continue in the 48-week long term extension (LTE) period and receive the same treatment up to Week 76.
Group 2: JNJ-77242113 Dose-2EXPERIMENTALParticipants will receive JNJ-77242113 Dose-2 tablets orally from Week 0 through Week 28. Participants who complete the Week 28 assessments and have achieved clinical response at Week 28 and who, in the opinion of the investigator, will continue to benefit from treatment with study intervention will continue in the 48-week LTE period and receive the same treatment up to Week 76.
Group 3: JNJ-77242113 Dose-3EXPERIMENTALParticipants will receive JNJ-77242113 Dose-3 tablets orally from Week 0 through Week 28. Participants who complete the Week 28 assessments and have achieved clinical response at Week 28 and who, in the opinion of the investigator, will continue to benefit from treatment with study intervention will continue in the 48-week LTE period and receive the same treatment up to Week 76.
Group 4: PlaceboEXPERIMENTALParticipants will receive placebo tablets orally from Week 0 through Week 28. Placebo-treated participants who meet the criteria of inadequate response at Week 16, will receive JNJ-77242113 Dose-3 tablet orally through Week 28. Participants who complete the Week 28 assessments and have achieved clinical response at Week 28 and who, in the opinion of the investigator, will continue to benefit from treatment with study intervention, will continue in the 48-week LTE period and receive the same treatment up to Week 76.
Group 1: JNJ-77242113 Dose 1EXPERIMENTALParticipants will receive JNJ-77242113 Dose 1 as delayed release tablets orally once daily from Week 0 through Week 16.
Group 2: JNJ-77242113 Dose 2EXPERIMENTALParticipants will receive JNJ-77242113 Dose 2 as delayed release tablets orally once daily from Week 0 through Week 16.
Group 3: PlaceboPLACEBO_COMPARATORParticipants will receive oral dose of matching placebo once daily from Week 0 through Week 16.
Group 1: JNJ-77242113 Dose 1 Once Daily (QD)EXPERIMENTALParticipants originally randomized to JNJ-77242113 Dose 1 QD in originating study 77242113PSO2001 will continue to receive JNJ-77242113 Dose 1 QD from Week 0 through Week 36 in this study.
Group 2: JNJ-77242113 Dose 2 QDEXPERIMENTALParticipants originally randomized to JNJ-77242113 Dose 2 QD in originating study 77242113PSO2001 will continue to receive JNJ-77242113 Dose 2 QD from Week 0 through Week 36 in this study.
Group 3: JNJ-77242113 Dose 3 QDEXPERIMENTALParticipants originally randomized to JNJ-77242113 Dose 3 QD in originating study 77242113PSO2001 will continue to receive JNJ-77242113 Dose 3 QD from Week 0 through Week 36 in this study.
Group 4: JNJ-77242113 Dose 1 Twice Daily (BID)EXPERIMENTALParticipants originally randomized to JNJ-77242113 Dose 1 BID in originating study 77242113PSO2001 will continue to receive JNJ-77242113 Dose 1 BID from Week 0 through Week 36 in this study.
Group 5: JNJ-77242113 Dose 3 BIDEXPERIMENTALParticipants originally randomized to JNJ-77242113 Dose 3 BID in originating study 77242113PSO2001 will continue to receive JNJ-77242113 Dose 3 BID from Week 0 through Week 36 in this study.
Group 6: JNJ-77242113 Dose 3 QDEXPERIMENTALParticipants originally randomized to placebo in originating Study 77242113PSO2001 will receive JNJ-77242113 Dose 3 QD from Week 0 through Week 36 in this study.
Group 1: JNJ-77242113 Dose 1 Once Daily (QD) and PlaceboEXPERIMENTALParticipants will receive JNJ-77242113 Dose 1 QD and placebo from Week 0 through Week 16. Participants will receive placebo to maintain the blinding of dose regimens.
Group 2: JNJ-77242113 Dose 2 QD and PlaceboEXPERIMENTALParticipants will receive JNJ-77242113 Dose 2 QD and placebo from Week 0 through Week 16. Participants will receive placebo to maintain the blinding of dose regimens.
Group 3: JNJ-77242113 Dose 3 QD and PlaceboEXPERIMENTALParticipants will receive JNJ-77242113 Dose 3 QD and placebo from Week 0 through Week 16. Participants will receive placebo to maintain the blinding of dose regimens.
Group 4: JNJ-77242113 Dose 1 Twice Daily (BID) and PlaceboEXPERIMENTALParticipants will receive JNJ-77242113 Dose 1 BID and placebo from Week 0 through Week 16. Participants will receive placebo to maintain the blinding of dose regimens.
Group 5: JNJ-77242113 Dose 3 BID and PlaceboEXPERIMENTALParticipants will receive JNJ-77242113 Dose 3 BID and placebo from Week 0 through Week 16. Participants will receive placebo to maintain the blinding of dose regimens.
Group 6: PlaceboPLACEBO_COMPARATORParticipants will receive placebo BID from Week 0 through Week 16.
Cohort 1: JNJ-77242113 Dose 1EXPERIMENTALParticipants will receive a single oral dose of JNJ-77242113 Dose 1 on Day 1.
Cohort 2: JNJ-77242113 Dose 2EXPERIMENTALParticipants will receive a single oral dose of JNJ-77242113 Dose 2 on Day 1.
Cohort 3: JNJ-77242113 Dose 3EXPERIMENTALParticipants will receive a single oral dose of JNJ-77242113 Dose 3 on Day 1.
Cohort 1: JNJ-77242113 or Placebo (Single Ascending Dose [SAD])EXPERIMENTALJapanese participants will receive single oral dose 1 of JNJ-77242113 (immediate-release \[IR\] tablet) or matching placebo on Day 1 in Cohort 1 of Part 1.
Cohort 2: JNJ-77242113 or Placebo (SAD)EXPERIMENTALJapanese participants will receive single oral dose 2 of JNJ-77242113 (IR tablet) or matching placebo on Day 1 in Cohort 2 of Part 1.
Cohort 3: JNJ-77242113 or Placebo (Single Dose [SD])EXPERIMENTALChinese participants will receive single oral dose 2 of JNJ-77242113 (IR tablet) or matching placebo on Day 1 in Cohort 3 of Part 2.
Cohort 4: JNJ-77242113 or Placebo (SD)EXPERIMENTALJapanese participants will receive single oral dose 3 of JNJ-77242113 (delayed-release \[DR\] tablet) with absorption enhancer (AbE) or matching placebo on Day 1 in Cohort 4 of Part 3.
Interventions
NameTypeDescription
JNJ-77242113DRUGJNJ-77242113 will be administered orally.
Matching Placebo to JNJ-77242113DRUGMatching placebo will be administered orally.
UstekinumabDRUGUstekinumab will be administered subcutaneously.
Matching Placebo to UstekinumabDRUGMatching placebo will be administered subcutaneously.
JNJ-77242113 Matching PlaceboDRUGJNJ-77242113 matching placebo will be administered orally.
DeucravacitinibDRUGDeucravacitinib will be administered orally.
Deucravacitinib Matching PlaceboDRUGDeucravacitinib matching placebo will be administered orally.
PlaceboDRUGPlacebo will be administered orally.
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Eligibility Criteria
Age Range12 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites160

Inclusion Criteria: * Diagnosis of plaque psoriasis, with or without psoriatic arthritis (PsA), prior to the first administration of study intervention * Total body surface area (BSA) greater than or equal to (\>=)10 percent (%) at screening and baseline * Total psoriasis area and severity index (P...

Countries:United StatesArgentinaAustraliaAustriaBelgiumCanadaDenmarkGermanyHungaryPolandPortugalSpainUnited KingdomBrazilRomaniaSouth KoreaTaiwanJapanTurkey (Türkiye)ChinaFranceItalyCzechiaIndiaMalaysia
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Recent Changes (Last 90 Days)
LOWJul 7, 2026NCT06143878lastUpdatePostDate: changed
LOWJul 7, 2026NCT06220604lastUpdatePostDate: changed
LOWJul 7, 2026NCT06220604lastUpdatePostDate: changed
LOWJul 7, 2026NCT06143878lastUpdatePostDate: changed
LOWJul 6, 2026NCT06934226lastUpdatePostDate: changed
LOWJul 6, 2026NCT06095102lastUpdatePostDate: changed
LOWJul 6, 2026NCT06095115lastUpdatePostDate: changed
LOWJul 6, 2026NCT06934226lastUpdatePostDate: changed
LOWJul 6, 2026NCT06095102lastUpdatePostDate: changed
LOWJul 6, 2026NCT06095115lastUpdatePostDate: changed
MEDIUMJul 2, 2026NCT05364554TRIAL_REMOVED: changed
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MEDIUMJul 2, 2026NCT05364554TRIAL_REMOVED: changed
LOWJun 25, 2026NCT06095102lastUpdatePostDate: changed
LOWJun 25, 2026NCT06220604lastUpdatePostDate: changed
LOWJun 25, 2026NCT06143878lastUpdatePostDate: changed
LOWJun 25, 2026NCT06095102lastUpdatePostDate: changed
LOWJun 25, 2026NCT06220604lastUpdatePostDate: changed
LOWJun 25, 2026NCT06143878lastUpdatePostDate: changed