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JNJ-87890387

Phase 1

Neoplasms | Small molecule | Oncology |Johnson & Johnson|Last Updated: Jun 5, 2026

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLEDBiomarker
Total Trials1
Total Enrollment200
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT06178614A Study of JNJ-87890387 for Advanced Solid TumorsPHASE1 RECRUITING 200Dec 14, 2023Feb 7, 2029Jun 5, 20266 United States, France +1
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Study Endpoints
Primary Endpoints
Part 1: Number of Participants with Dose Limiting Toxicity (DLTs)
Up to first 21 days after administration of the first full treatment dose

Number of participants with DLTs will be reported. The DLTs are adverse events including certain high grade non-hematologic or hematologic toxicities, or toxicities meeting other specific criteria.

Part 1 and Part 2: Number of Participants with Adverse Events (AEs) by Severity
Up to 2 years 9 months

An AE is any untoward medical occurrence in a clinical study participant administered an investigational or non-investigational product and it does not necessarily have a causal relationship with the investigational product. Severity will be graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) version 5.0 with the exception of cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome events (ICANS), which will be graded by American Society for Transplantation and Cellular Therapy (ASTCT) guidelines. Severity scale ranges from grade 1 (mild) to grade 5 (death). Grade 1= mild, Grade 2= moderate, Grade 3= severe, Grade 4= life-threatening and Grade 5= death related to adverse event.

Secondary Endpoints
Part 1 and Part 2: Serum Concentration of JNJ-87890387
Up to 2 years 9 months
Part 1 and Part 2: Maximum Observed Serum Concentration (Cmax) of JNJ-87890387
Up to 2 years 9 months
Part 1 and Part 2: Time to Reach Maximum Observed Serum Concentration (Tmax) of JNJ-87890387
Up to 2 years 9 months
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Study Design & Arms
AllocationNA
MaskingNONE
ModelSEQUENTIAL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
JNJ-87890387EXPERIMENTALIn Part 1 (Dose escalation) participants will receive JNJ-87890387. The dose will be escalated sequentially until the recommended phase 2 dose (RP2D) regimen(s) have been identified. In Part 2 (Dose expansion), participants will receive JNJ-87890387 at the RP2D regimen(s) determined in Part 1.
Interventions
NameTypeDescription
JNJ-87890387DRUGJNJ-87890387 will be administered.
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites6

Inclusion Criteria: * Have histologically or cytologically confirmed, metastatic, or unresectable solid tumor of one of the following types: a) Renal cell cancer (RCC)-clear cell or papillary carcinoma; b) Endometrioid ovarian cancer c) Endometrioid uterine carcinoma; d) Colorectal adenocarcinoma (...

Countries:United StatesFranceSpain
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Recent Changes (Last 90 Days)
LOWJun 5, 2026NCT06178614lastUpdatePostDate: changed
LOWJun 5, 2026NCT06178614lastUpdatePostDate: changed
LOWJun 5, 2026NCT06178614lastUpdatePostDate: changed
LOWJun 5, 2026NCT06178614lastUpdatePostDate: changed
LOWMay 26, 2026NCT06178614primaryCompletionDate: changed
LOWMay 24, 2026NCT06178614studyFirstPostDate: changed