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CG5503 IR; tapentadol

Phase 3

Osteoarthritis | Small molecule | Musculoskeletal |Johnson & Johnson|Last Updated: Jun 15, 2011

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindUNCONTROLLED
Total Trials1
Total Enrollment669

FDA Designations

No designations recorded

Clinical trial landscape

CG5503 IR; tapentadol · 1 trial · 3 indications

Phase 3 1
NCT00361582A Study to Evaluate the Effectiveness and Safety of Multiple Doses of Tapentadol(CG5503) in Patients Awaiting Joint Replacement SurgeryOsteoarthritis
COMPLETED669 Analytics
PHASE3COMPLETED
A Study to Evaluate the Effectiveness and Safety of Multiple Doses of Tapentadol(CG5503) in Patients Awaiting Joint Replacement Surgery
OsteoarthritisUnlock trial analytics

Study Endpoints

Primary Endpoints

The primary efficacy outcome is the SPID (Sum of Pain Intensity Difference) calculated at 5 days.

Secondary Endpoints

Secondary efficacy outcomes include, among others, the time to the first use of rescue medication, the distribution of responder rates, and the SPID over 2 and 10 days.
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT

Interventions

NameTypeDescription
CG5503 IR; tapentadolDRUG -
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Eligibility Criteria

Age Range18 Years to 80 Years
SexALL
Healthy VolunteersNo

Inclusion Criteria: * Clinical diagnosis of chronic osteoarthritis of the hip or the knee based on clinical and radiographic (X-Ray) criteria defined by standard accepted guidelines * candidate (qualifies) for primary one-sided total or partial joint replacement surgery due to noninflammatory, end-...

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Frequently asked questions about CG5503 IR; tapentadol

What is CG5503 IR (tapentadol) used for?

CG5503 IR (tapentadol) is an investigational small molecule being studied for the treatment of arthralgia and osteoarthritis. It is being evaluated in patients awaiting joint replacement surgery and in the treatment of acute pain from bunionectomy. The drug is in Phase 3 clinical development.

Who makes CG5503 IR (tapentadol)?

CG5503 IR (tapentadol) is being developed by Johnson & Johnson (NYSE: JNJ). The company is conducting Phase 3 clinical trials to evaluate the drug's effectiveness and safety in patients with osteoarthritis and arthralgia.

What phase is CG5503 IR (tapentadol) in?

CG5503 IR (tapentadol) is in Phase 3 clinical development. It is an investigational drug and has not been approved by regulatory authorities. Two Phase 3 trials have been completed, one in patients awaiting joint replacement surgery and another in patients with acute pain from bunionectomy.

What clinical trials is CG5503 IR (tapentadol) in?

CG5503 IR (tapentadol) has completed two Phase 3 clinical trials. NCT00361582 evaluated multiple doses in 669 patients awaiting joint replacement surgery for osteoarthritis. NCT00364247 evaluated the drug in 602 patients with acute pain from bunionectomy compared with placebo, followed by an open-label extension.

Is CG5503 IR (tapentadol) the same as tapentadol?

Yes, CG5503 IR is the same drug as tapentadol. The name CG5503 IR refers to the immediate-release formulation of tapentadol, which is being studied in Phase 3 clinical trials for the treatment of arthralgia and osteoarthritis.