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drug-eluting stent, bare-metal stent

Phase 2

Peripheral Artery Disease | Unknown | Cardiovascular |Cardinal Health, Inc.|Last Updated: Feb 4, 2010

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindACTIVE_CONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment93
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00232869A Study of the SMART Stent in the Treatment SFA Disease.PHASE2 COMPLETED 93Feb 1, 2001May 1, 2009Feb 4, 20101 Germany
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Study Endpoints
Primary Endpoints
In-stent mean lumen diameter percent stenosis via quantitative angiography.
6 months.
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
1EXPERIMENTALSirolimus Coated Cordis SMART™ nitinol selfexpandable stent
2ACTIVE_COMPARATORSMART™ bare-metal stent
Interventions
NameTypeDescription
drug-eluting stentDEVICESirolimus Coated Cordis SMART™ nitinol selfexpandable stent
bare-metal stentDEVICESMART™ bare-metal stent
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Eligibility Criteria
Age Range30 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: 1. One superficial femoral artery presenting \> 70% stenosis(es) or total occlusion 2. Symptomatic leg ischemia by Rutherford Classification (category 1, 2, 3 or 4) Exclusion Criteria: 1. Tissue loss due to ischemic disease (Rutherford category 5 or 6). 2. Tandem lesion requir...

Countries:Germany
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