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CRESTOR

Phase 3

Heart Failure | Small molecule | Cardiovascular |AstraZeneca PLC|Last Updated: Nov 19, 2010

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindUNCONTROLLED
Total Trials1
Total Enrollment5,013

FDA Designations

No designations recorded

Clinical trial landscape

CRESTOR · 1 trial · 1 indication

Phase 3 1
NCT00206310Crestor Versus Placebo in Subjects With Heart FailureHeart Failure
COMPLETED5,013 Analytics
PHASE3COMPLETED
Crestor Versus Placebo in Subjects With Heart Failure
Heart FailureUnlock trial analytics

Study Endpoints

Primary Endpoints

The primary objective of this study is to determine whether rosuvastatin reduces the combined endpoint of cardiovascular death or non-fatal myocardial infarction (MI) or non-fatal stroke (time to first event).

Secondary Endpoints

The secondary objectives are to evaluate the effects of rosuvastatin on:
Total mortality
Any coronary event defined as the combined endpoint of sudden death or fatal or non-fatal MI or Percutaneous Transluminal Coronary Angioplasty (PTCA) or Coronary Artery Bypass Grafting (CABG) or defibrillation of ventricular fibrillation by an implant
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposePREVENTION

Interventions

NameTypeDescription
CRESTORDRUG -
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Eligibility Criteria

Age Range60 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites375

Inclusion Criteria: * Chronic symptomatic systolic heart failure of ischaemic aetiology as judged by the investigator, optimal therapy for chronic symptomatic systolic heart failure according to the investigator Exclusion Criteria: * Acute myocardial infarction within 6 months before randomizatio...

Countries:BelgiumBulgariaCzechiaDenmarkFinlandFranceGermanyHungaryIrelandNetherlandsNorwayPolandPortugalRomaniaRussiaSlovakiaSouth AfricaSpainSwedenSwitzerlandUnited Kingdom
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Frequently asked questions about CRESTOR

What is CRESTOR used for in heart failure?

CRESTOR is a small molecule being studied for heart failure. It is an investigational treatment evaluated in a Phase 3 clinical trial in patients with heart failure. The study compared CRESTOR to placebo in subjects with heart failure, with a total enrollment of 5,013 participants.

Who makes CRESTOR?

CRESTOR is developed by AstraZeneca PLC, a biopharmaceutical company listed on the stock exchange under the ticker AZN. AstraZeneca is conducting clinical research to evaluate CRESTOR for the treatment of heart failure.

What phase is CRESTOR in?

CRESTOR is in Phase 3 clinical development for heart failure. It is an investigational drug, meaning it has not been approved for this use and is still being studied in clinical trials. One Phase 3 trial has been completed.

What clinical trials is CRESTOR in?

CRESTOR has one completed Phase 3 clinical trial, identified as NCT00206310, titled "Crestor Versus Placebo in Subjects With Heart Failure." The trial enrolled 5,013 participants and was conducted in multiple countries including Belgium, France, Germany, Spain, the United Kingdom, and the United States.

Is CRESTOR the same as rosuvastatin?

CRESTOR is a brand name for rosuvastatin, a medication in the statin class. In the context of heart failure, it is being studied as an investigational treatment. The clinical trial NCT00206310 evaluated CRESTOR versus placebo in subjects with heart failure.