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ATACAND

Phase 3

Hypertension | Small molecule | Cardiovascular |AstraZeneca PLC|Last Updated: Aug 30, 2011

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindUNCONTROLLED
Total Trials1
Total Enrollment1,000

FDA Designations

No designations recorded

Clinical trial landscape

ATACAND · 1 trial · 1 indication

Phase 3 1
NCT00227318TROPHY - Candesartan Cilexetil Long-term Hypertension Prevention TrialHypertension
COMPLETED1,000 Analytics
PHASE3COMPLETED
TROPHY - Candesartan Cilexetil Long-term Hypertension Prevention Trial
HypertensionUnlock trial analytics

Study Endpoints

Primary Endpoints

To determine whether candesartan cilexetil 16 mg compared to placebo reduces the crude incidence of hypertension in a population with high normal BP evaluated after a 4-year study period consisting of 2 years of double-blind treatment followed by 2 years

Secondary Endpoints

To evaluate the reduction in BP after 2 years treatment with candesartan cilexetil 16 mg vs placebo in patients with high normal BP.
To evaluate the incidence of hypertension after 2 years treatment with candesartan cilexetil 16 mg vs placebo in patients with high normal BP.
To evaluate Health-related Quality of Life yearly during 2 years treatment with candesartan cilexetil 16mg vs placebo and yearly during a 2-year follow up period in patients with high normal BP.
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
PurposePREVENTION

Interventions

NameTypeDescription
ATACANDDRUG -
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Eligibility Criteria

Age Range30 Years to 65 Years
SexALL
Healthy VolunteersNo
Study Sites42

Inclusion Criteria: * Subjects between the ages of 30 and 65 (inclusive) at the time of the informed consent process * have an average clinic BP in the high normal range of \< 139/85-89 mmHg or 130-139/\< 89 mm Hg (high normal BP range) (mean systolic and/or diastolic pressure based on 3 consecutiv...

Countries:United States
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Frequently asked questions about ATACAND

What is ATACAND used for?

ATACAND is used for the treatment of hypertension, or high blood pressure. It is a small molecule cardiovascular therapy being developed by AstraZeneca PLC. The drug is currently in Phase 3 clinical development for this indication.

What does ATACAND target?

ATACAND is a small molecule that targets the angiotensin II receptor, a key component in blood pressure regulation. By blocking this receptor, it helps to lower blood pressure in patients with hypertension. This mechanism is central to its role in cardiovascular therapy.

Who makes ATACAND?

ATACAND is being developed by AstraZeneca PLC, a multinational pharmaceutical company listed on the stock exchange under the ticker AZN. AstraZeneca is responsible for the clinical development and potential commercialization of this hypertension treatment.

What phase is ATACAND in?

ATACAND is in Phase 3 clinical development for hypertension. It has completed one Phase 3 trial, the TROPHY study, which was a randomized, double-blind trial with 1,000 participants. The drug is still investigational and has not yet been approved for commercial use.

What clinical trials is ATACAND in?

ATACAND has been studied in the TROPHY trial (NCT00227318), a Phase 3 study titled 'Candesartan Cilexetil Long-term Hypertension Prevention Trial'. This completed trial enrolled 1,000 patients with hypertension in the United States, with participants aged 30 years and older.

Is ATACAND the same as candesartan cilexetil?

Yes, ATACAND is the brand name for candesartan cilexetil, as indicated by the TROPHY trial title. This medication is being developed for hypertension and is currently in Phase 3 clinical trials. It is important to note that it remains investigational and is not yet approved.