Recent Updates
Recently added Catalysts

ABT-874/Human monoclonal antibody against IL-12

Phase 2

Multiple Sclerosis | Small molecule | Immunology |AbbVie Inc.|Last Updated: Jan 4, 2013

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment215
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00086671Safety and Effectiveness of Two Doses of ABT-874 as Compared to Placebo in Subjects With Multiple Sclerosis (MS)PHASE2 COMPLETED 215Apr 1, 2004Nov 1, 2006Jan 4, 201344 United States, Canada +3
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
Comparison of the cumulative number of Gd enhanced (T1 weighted) lesions during the treatment phase
24 weeks
Safety and clinical laboratory parameters
monthly
vital signs
monthly
Secondary Endpoints
Magnetic Resonance Imaging endpoints
Screening
Unlock Study Endpoints
Study Design & Arms
AllocationRANDOMIZED
MaskingTRIPLE
ModelPARALLEL
Treatment Arms
ArmTypeDescription
ABT-874 200 mg weeklyEXPERIMENTAL -
PlaceboPLACEBO_COMPARATOR -
ABT 874 QOWEXPERIMENTAL -
Interventions
NameTypeDescription
ABT-874/Human monoclonal antibody against IL-12DRUG -
PlaceboDRUG -
Unlock Study Design Details
Eligibility Criteria
Age Range18 Years — 60 Years
SexALL
Healthy VolunteersNo
Study Sites44

Inclusion Criteria: * Age between 18 and 55 years * Diagnosis of active relapse within 12 months of screening. * At least one relapse within 12 months of screening. * Must be able to walk at least 65 feet with or without assistance * Off Copaxone or interferon therapy for two months prior to screen...

Countries:United StatesCanadaGermanyNetherlandsUnited Kingdom
Unlock Eligibility Criteria