Approval Probability
TA Base Rate
Adjusted LOA
ML Risk
Clozapine · 1 trial · 1 indication
| Arm | Type | Description |
|---|---|---|
| A | ACTIVE_COMPARATOR | - |
| B | EXPERIMENTAL | - |
| Name | Type | Description |
|---|---|---|
| Clozapine | DRUG | Clozapine 25 or 100 mg tablets. Patients were initially titrated over the first 10 days to 300 mg/day and remained at this dose for 1 week. Thereafter, the dose could be varied between 250 and 600 mg/day based on response and tolerability for a total treatment duration of 18 weeks |
| Ziprasidone | DRUG | Ziprasidone 40, 60, or 80 mg capsules. Patients were initially titrated over the first 3 days to 80 mg/day, which could subsequently be increased to between 80 and 160 mg/day based on response and tolerability for a total treatment duration of 18 weeks |
Inclusion Criteria: * CGI - S ≥4 * PANSS ≥ 80 * Inpatients or outpatients Exclusion Criteria: * Patients with a history of myeloproliferative diseases, history of granulocytopenia, agranulocytosis due to a drug * Diagnosis of substance dependence within previous 3 months using DSM-IV criteria * H...
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