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Fluticasone Propionate MDPI

Phase 1

Asthma | Small molecule | Respiratory |Teva Pharmaceutical Industries Limited|Last Updated: Nov 9, 2021

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindACTIVE_CONTROLLEDBiomarker
Total Trials1
Total Enrollment20
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT02680561A Double Blind Open Label Comparator Study to Compare Treatments in 4 to 11 Year Old Patients With AsthmaPHASE1 COMPLETED 20Apr 1, 2016Aug 1, 2016Nov 9, 20213 United States
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Study Endpoints
Primary Endpoints
Maximum observed plasma drug concentration (Cmax)
4 months
Area under the plasma drug concentration-time curve (AUCO-t)
4 months
Secondary Endpoints
Time to maximum observed plasma drug concentration (tmax)
4 months
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelCROSSOVER
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Treatment A: Fp MDPIEXPERIMENTALSingle inhalation dose of Fluticasone Propionate Multidose Dry Powder Inhaler (Fp MDPI) on Day 1 into 1 of 6 treatment sequences (ABC, BCA, CAB, ACB, BAC, or CBA)
Treatment B: FS MDPIEXPERIMENTALSingle inhalation dose of Fluticasone Propionate/Salmeterol Multidose Dry Powder Inhaler (FS MDPI) on Day 1 into 1 of 6 treatment sequences (ABC, BCA, CAB, ACB, BAC, or CBA)
Treatment C: ComparatorACTIVE_COMPARATORSingle inhalation dose of fluticasone propionate/salmeterol (ADVAIR DISKUS) on Day 1 into 1 of 6 treatment sequences (ABC, BCA, CAB, ACB, BAC, or CBA)
Interventions
NameTypeDescription
Fluticasone Propionate MDPIDRUG -
Fluticasone Propionate/Salmeterol MDPIDRUG -
Fluticasone propionate/salmeterolDRUG -
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Eligibility Criteria
Age Range4 Years — 11 Years
SexALL
Healthy VolunteersNo
Study Sites3

Inclusion Criteria: * The patient is a male or female aged 4 through 11 years of age, inclusive * Severity of disease: The patient has persistent asthma * Asthma diagnosis: The patient has a diagnosis of asthma as defined by the NIH. * The patient has required less than 4 inhalations per week of re...

Countries:United States
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