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Flovent HFA pressurized metered dose inhaler

Phase 3

Asthma | Small molecule | Respiratory |Teva Pharmaceutical Industries Limited|Last Updated: Sep 1, 2021

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment1,902
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT03879837Therapeutic Equivalence of Fluticasone Propionate Pressurized Metered Dose Inhaler, 110 mcg, to Flovent® HFA 110 mcgPHASE3 COMPLETED 1,902Mar 25, 2019Jul 9, 2021Sep 1, 20211 United States
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Study Endpoints
Primary Endpoints
Mean change in baseline adjusted morning pre-dose FEV1 from the time of treatment randomization to Week 4.
4 weeks
Secondary Endpoints
Superiority over Placebo
Approximately 4 Weeks
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Investigational Test ProductEXPERIMENTALFluticasone propionate pressurized metered dose inhaler, 110 mcg per actuation
Reference Listed DrugACTIVE_COMPARATORFlovent HFA pressurized metered dose inhaler, 110 mcg per actuation
PlaceboPLACEBO_COMPARATORPlacebo pressurized metered dose inhaler, no active content
Interventions
NameTypeDescription
Fluticasone propionate pressurized metered dose inhalerDRUG110 mcg per actuation
Flovent HFA pressurized metered dose inhalerDRUG110 mcg per actuation
Placebo pressurized metered dose inhalerDRUGno active content
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Eligibility Criteria
Age Range18 Years — 75 Years
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: 1. Adult ≥18 and ≤75 years of age male or female subjects of non-child bearing potential or of child bearing potential committing to consistent and correct use of an acceptable method of birth control. 2. Body mass index (BMI) ≥18 and ≤45. 3. Diagnosis of asthma, as defined by t...

Countries:United States
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